Browsing Faculty of Natural Sciences by Author "Henkel, Ralf"
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High levels of oxidation–reduction potential in frozen-thawed human semen are significantly correlated with poor post-thaw sperm quality
Henkel, Ralf; Saleh, Ramadan; Elsuity, Mohamed A. (Wiley-Blackwell, 2020)This study examined the relationship between oxidation–reduction potential (ORP) in frozen-thawed semen and the post-thaw sperm parameters. Levels of ORP were measured in 25 samples from men presenting for routine infertility ... -
Human sperm handling in intracytoplasmic sperm injection processes: In vitro studies on mouse oocyte activation, embryo development competence and sperm oxidation–reduction potential
Roychoudhury, S.; Maldonado-Rosas, I.; Agarwal, A.; Esteves, S.C.; Henkel, Ralf; Sharma, Rajan (Wiley, 2018)Polyvinylpyrrolidone (PVP) and hyaluronic acid (HA) are routinely used in handling spermatozoa for intracytoplasmic sperm injection (ICSI). As there are still concerns about possible adverse effects on the embryo, this ... -
Impact of body composition analysis on male sexual function: A metabolic age study
Majzoub, Ahmad; Elbardisi, Haitham; Henkel, Ralf (Frontiers Media, 2023)Metabolic Age (MetAge) and body composition analysis may reflect an individual’s metabolic status, which is believed to influence male sexual and gonadal functions. Although erectile dysfunction (ED) and hypogonadism ... -
The impact of Covid-19 vaccines on male semen parameters: A retrospective cohort study
Henkel, Ralf; Leisegang, Kristian; Finelli, Renata (University of the Western Cape, 2023)The emergence of SARS-CoV-2 and the subsequent COVID-19 pandemic necessitated the development of adequate vaccines. Despite vaccines being demonstrated to be safe and effective for preventing severe disease and death, ... -
The impact of male overweight on semen quality and outcome of assisted reproduction
Leisegang, Kristian; Henkel, Ralf (Medknow Publications, 2014)The impact of obesity on male reproductive health remains a contested topic as evidence is inconclusive and inconsistent. Even more debatable is the effect of male obesity in assisted reproduction. In the manuscript, ... -
The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment
Lewis, Sheena E.M.; Aitken, R. John; Conner, Sarah J.; De Iuliis, Geoffry; Evenson, Donald P.; Henkel, Ralf; Giwercman, Aleksander; Gharagozloo, Parviz (Elsevier, 2013)Sperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of assisted reproduction outcomes. It is associated with reduced fertilization rates, embryo quality and pregnancy rates, and higher ... -
Impact of Varicocele Repair on Semen Parameters in Infertile Men: A Systematic Review and Meta-Analysis
Ashok, Agarwal; Cannarella, Rossella; Henkel, Ralf; Raghavender, Kosgi (Korean Society for Sexual Medicine and Andrology, 2023)Purpose: Despite the significant role of varicocele in the pathogenesis of male infertility, the impact of varicocele repair (VR) on conventional semen parameters remains controversial. Only a few systematic reviews and ... -
In Silico Sperm Proteome Analysis to Investigate DNA Repair Mechanisms in Varicocele Patients
Henkel, Ralf; Finelli, R; Darbandi, S; Pushparaj, P. N.; Ko, E.; Agarwal, A. (Frontiers Media S.A., 2021-12-17)Varicocele, a condition associated with increased oxidative stress, negatively affects sperm DNA integrity and reduces pregnancy rates. However, the molecular mechanisms related to DNA integrity, damage, and repair in ... -
In vitro effects of aqueous extract of unfermented rooibos on human spermatozoa
Henkel, Ralf; Takalani, Ndivhuho; Gbenga, Adefolaju; Chinyerum, Opuwari (Wiley, 2022)The inability to conceive is a baleful experience for thousands of couples worldwide. Among different well-known reproductive techniques, medicinal plants have been utilized to treat male infertility. Medicinal plants, ... -
In vivo effects of eurycoma longifolia Jack (Tongkat Ali) extract on reproductive functions in the rat
Solomon, Michael; Erasmus, N.; Henkel, Ralf (Blackwell, 2013)An aqueous extract of Eurycoma longifolia (Tongkat Ali; TA) roots is traditionally used to enhance male sexuality. Because previous studies are limited to only few sperm parameters or testosterone concentration, this study ... -
An in-depth bibliometric analysis and current perspective on male infertility research
Baskaran, Saradha; Agarwal, Ashok; Leisegang, Kristian; Peter, Natesan Pushparaj; Selvam, Manesh Kumar Panner; Henkel, Ralf (Korean Society for Sexual Medicine and Andrology, 2019)PURPOSE: Male infertility is emerging as a major, escalating global health problem that imposes the need to investigate research trends in male infertility. The purpose of this study is to analyze male infertility research ... -
Inorganic ions in leonotis leonurus extract do not explain changes in isolated Wistar rat heart function
Burger, Andries; Mugabo, Pierre; Henkel, Ralf; Green, Ivan (Open Access Science Research Publisher, 2011)Leonotis leonurus (L. leonurus) R. Br (Lamiaceae) is used by healers in South Africa. The present study was conducted to determine if the L. leonurus effect on isolated rat heart is due to ionic changes in the perfusion fluid. -
Interpretation of semen analysis using WHO 1999 and WHO 2010 reference values: abnormal becoming normal
Alshahrani, S.; Aldossari, K.; Al-Zahrani, J.; Gabr, A. H.; Henkel, Ralf; Ahmad, G. (Wiley, 2017)Reference values of WHO 1999 manual were used for the interpretation of semen analysis until 2010 when new reference values were introduced which have lower cut-off compared to WHO 1999. Therefore, several men who previously ... -
Is there plagiarism in the most influential publications in the field of andrology?
Baskaran, Saradha; Henkel, Ralf; Leisegang, Kristian (Wiley, 2019)Plagiarism is a common form of academic misconduct that extensively jeopardises the quality of scientific publication. The purpose of this study is to determine the extent of plagiarism in the most influential andrology ... -
Is there plagiarism in the most influential publications in the field of andrology?
Henkel, Ralf (Wiley Online Library, 2019)Plagiarism is a common form of academic misconduct that extensively jeopardises the quality of scientific publication. The purpose of this study is to determine the extent of plagiarism in the most influential andrology ... -
Male age and progressive sperm motility are critical factors affecting embryological and clinical outcomes in oocyte donor ICSI cycles
Henkel, Ralf (Reproductive Sciences, 2021)This retrospective cohort study aimed to explore whether paternal age and semen quality parameters affect the embryological and clinical outcomes of ICSI with oocyte donation. A total of 339 oocyte donation (OD)-ICSI cycles ... -
Male infertility, oxidative stress and antioxidants
Zhaku, Vegim; Agarwal, Ashok; Henkel, Ralf (IntechOpen, 2021)Within the male reproductive system, oxidative stress (OS) has been identified as prevailing etiology of male infertility. The effects of reactive oxygen species (ROS) on male fertility depend on the dimensions, “modus ... -
Microtubular dysfunction and male infertility
Gunes, Sezgin; Sengupta, Pallav; Henkel, Ralf; Alguraigari, Aabed; Sinigaglia, Mariana Marques; Kayal, Malik; Joumah, Ahmad; Agarwal, Ashok (Korean Society for Sexual Medicine and Andrology, 2018)Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain ... -
The new 6th edition of the WHO laboratory manual for the examination and processing of human semen: Is it a step toward better standard operating procedure?
Chung, Eric; Arafa, Mohamed; Henkel, Ralf (Shanghai Institute Materia Medica, 2021)Semen analysis (SA) remains the cornerstone of male infertility evaluation and should ideally be performed by an accredited andrology laboratory or in vitro fertilization (IVF) clinics based on the standards defined ... -
Novel additive for sperm cryopreservation media: Holotheria parva coelomic cavity extract protects human spermatozoa against oxidative stress—A pilot study
Henkel, Ralf; Khashavi, Zahra; Homaei, Ahmad (Wiley-Blackwell, 2020)Cryopreservation is the most effective method for preserving semen for a long period of time. However, during the freeze–thaw process, production of reactive oxygen species (ROS) leads to a steep reduction in sperm fertility ...