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Winter is coming: A southern hemisphere perspective of the environmental drivers of sars-cov-2 and the potential seasonality of covid-19
(MPDI, 2020)
SARS-CoV-2 virus infections in humans were first reported in December 2019, the boreal winter. The resulting COVID-19 pandemic was declared by the WHO in March 2020. By July 2020, COVID-19 was present in 213 countries and ...
The impact of COVID-19 on the male reproductive tract and fertility: A systematic review
(Informa UK Limited, trading as Taylor & FrancisGroup., 2021)
Objective: The COVID-19 pandemic, caused by the acute respiratory syndrome-coronavirus 2
(SARS-CoV-2), remains an ongoing public health challenge. Although males are affected slightly more
than females, the impact of ...
Development of Effective Therapeutic Molecule from Natural Sources against Coronavirus Protease
(MDPI, 2021)
Abstract: The SARS-CoV-2 main protease (Mpro) is one of the molecular targets for drug design. Effective vaccines have been identified as a long-term solution but the rate at which they are being administered is slow in ...
Understanding the epidemiology, pathophysiology, diagnosis and management of SARS-CoV-2
(SAGE, 2020)
The emergence of coronavirus disease 2019 (COVID-19) in December 2019 has resulted in over 20 million cases and 741,808 deaths globally, affecting more than 200 countries. COVID-19 was declared a pandemic on 11 March 2020 ...
Genome sequencing of a severe acute respiratory syndrome Coronavirus 2 isolate obtained from a South African patient with Coronavirus disease 2019
(American Society for Microbiology, 2020)
As a contribution to the global efforts to track and trace the ongoing coronavirus pandemic, here we present the sequence, phylogenetic analysis, and modeling of nonsynonymous mutations for a severe acute respiratory ...
South Africa: Challenges and successes of the COVID-19 lockdown
(Elsevier, 2020)
At the beginning of March 2020, South Africa (59 million inhabitants) was hit by the pandemic of COVID-19 and soon became the most affected country in Africa by the SARS-CoV-2 virus. From one single case on March 5th, the ...
Inhibitory potential of repurposed drugs against the SARS-CoV-2 main protease: A computational-aided approach
(Taylor and Francis, 2020)
The exponential increase in cases and mortality of coronavirus disease (COVID-19) has called for a need to develop drugs to treat this infection. Using in silico and molecular docking approaches, this study investigated ...
Dispersal dynamics of SARS-CoV-2 lineages during the first epidemic wave in New York City
(Public Library of Science, 2021)
During the first phase of the COVID-19 epidemic, New York City rapidly became the epicenter of the pandemic in the United States. While molecular phylogenetic analyses have previously highlighted multiple introductions and ...
Mathematical study of transmission dynamics of SARS-CoV-2 with waning immunity
(AIMS Press, 2022)
The aim of this work is to provide a new mathematical model that studies transmission
dynamics of Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). The model ...
The flexible, extended coil of the pdz-binding motif of the three deadly human coronavirus e proteins plays a role in pathogenicity
(MDPI, 2022)
The less virulent human (h) coronaviruses (CoVs) 229E, NL63, OC43, and HKU1 cause
mild, self-limiting respiratory tract infections, while the more virulent SARS-CoV-1, MERS-CoV, and
SARS-CoV-2 have caused severe outbreaks. ...