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K21 compound, a potent antifungal agent: Implications for the treatment of fluconazole-resistant HIV-associated Candida species
(Frontiers, 2019-05-24)
Background/objectives: With mucocutaneous candidiasis being highly prevalent in HIV patients, the emergence of fluconazole-resistant Candida species forms a major challenge in treating and eradicating these infections. The ...
Oral health status and treatment needs of pregnant women attending antenatal clinics in KwaZulu-Natal, South Africa
(Hindawi, 2019)
During pregnancy, the oral cavity is characterised by an acidic environment and an inflammatory response brought about by vomiting and changes in hormonal levels, respectively, thereby increasing the mother’s risk of ...
Carica papaya seed extract slows human sperm
(Elsevier, 2019)
Ethnopharmacological relevance: Traditional healers use Carica papaya seeds as a remedy for diseases and as a contraceptive for men and abortion in women.
Material and methods: Semen samples from 35 healthy men were allowed ...
Sensitive electrochemical determination of ethambutol in pharmaceutical formulation and human urine at nickel nanoparticles/electrochemically reduced graphene oxide modified electrode
(Chemical Society of Ethiopia, 2019)
This paper describes the application of nickel nanoparticles decorated electrochemically reduced
graphene oxide modified glassy carbon electrode (NiNPs/ERGO/GCE) for the determination of ethambutol
(ETB), an anti-Mycobacterium ...
Efficient numerical method for a model arising in biological stoichiometry of tumor dynamics
(American Institute of Mathematical Sciences, 2019)
In this paper, we extend a system of coupled first order non-linear system of delay differential equations (DDEs) arising in modeling of stoichiometry of tumour dynamics, to a system of diffusion-reaction system of partial ...
A fitted numerical method for a model arising in HIV-related cancer-immune system dynamics
(Tianjin Polytechnic University, 2019)
The effect of diseases such as cancer and HIV among our societies is evident. Thus, from the mathematical
point of view many models has been developed with the aim to contribute towards understanding the dynamics
of ...
Structure based identification of novel inhibitors against ATP synthase of Mycobacterium tuberculosis: A combined in silico and in vitro study
(International Journal of Biological Macromolecules, 2019)
The shortcomings of conventional tuberculosis treatments resulting from the development of drug resistance in
Mycobacteriumtuberculosis drive a need for the formulation of novel therapeutic agents. The diarylquinoline ...
Designing novel possible kinase inhibitor derivatives as therapeutics against Mycobacterium tuberculosis: An in silico study
(Scientific Reports, 2019)
Rv2984 is one of the polyphosphate kinases present in Mycobacterium tuberculosis involved in the
catalytic synthesis of inorganic polyphosphate, which plays an essential role in bacterial virulence
and drug resistance. ...
A fitted operator method for tumor cells dynamics in their micro-environment
(Tianjin Polytechnic University, 2019)
In this paper, we consider a quasi non-linear reaction-diffusion model designed to mimic tumor cells’
proliferation and migration under the influence of their micro-environment in vitro. Since the model can be used
to ...
Numerical solution for a problem arising in angiogenic signalling
(American Institute of Mathematical Sciences, 2019)
Since the process of angiogenesis is controlled by chemical signals, which stimulate
both repair of damaged blood vessels and formation of new blood vessels, then other chemical
signals known as angiogenesis inhibitors ...