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Bioprospecting of Helichrysum species: Chemical profile, phytochemical properties, and antifungal efficacy against botrytis cinerea
(MDPI, 2023)
Variation in plant species and extraction solvents play a crucial role in the recovery of
their bioactive compounds and antifungal efficacy. Thus, in this study, a comparative investigation
was carried out using extraction ...
In-silico and in-vivo evaluation of the cardiovascular effects of five Leonotis leonurus diterpenes
(Obikeze, K. et al. (2023). In-silico and in-vivo evaluation of the cardiovascular effects of five Leonotis leonurus diterpenes. Scientific African, 19, e01510. 10.1016/j.sciaf.2022.e01510, 2023)
Leonotis leonurus extracts and compounds have been extensively studied for pharmacological effects. However, most of the diterpenes isolated from the plant have not been evaluated as possible contributors to the cardiovascular ...
The implementation of a risk based assessment approach by the South African Health pProducts Regulatory Authority (SAHPRA)
(Springer, 2023)
An extensive backlog of pending regulatory decisions is one of the major historical challenges that the South
African Health Products Regulatory Authority (SAHPRA) inherited from the Medicine Control Council (MCC). Revising ...
Green synthesized saunps as a potential delivery platform for cytotoxic alkaloids
(MDPI, 2023)
The use of natural products as chemotherapeutic agents is well established. However, many
are associated with undesirable side effects, including high toxicity and instability. Previous reports
on the cytotoxic activity ...
Assessment of thermal and hydrolytic stabilities and aqueous solubility of artesunate for formulation studies
(AAPS PharmSciTech, 2023)
For the purpose of establishing the optimum processing parameters and storage conditions associated with nanolipid formulations of the artemisinin derivative artesunate, it was necessary to evaluate the thermal stability ...
Evaluation of Terminalia macroptera (Combretaceae) Guill. & Perr stem bark extract incorporated into an emulgel for the potential management of rheumatoid arthritis
(Scientific African, 2023)
Background: Rheumatoid Arthritis (RA) is a chronic disease which causes inflammation and damage to the joint. The goals of treatment are to stop inflammation, relieve symptoms, improve physical function and overall well-being. ...
A retrospective analysis of applications for registration of generic medicines processed by the medicines control authority of Zimbabwe
(Springer, 2023)
Many applications for registration of medicines are rejected because applicants fail to submit or resolve critical
deficiencies in the quality, efficacy, and safety of the medicines. The study aimed to establish approval ...
Common Deficiencies Found in the Active Pharmaceutical Ingredient (API) Section of Non-sterile Generic Products Submitted for Registration by SAHPRA
(Springer Science and Business Media Deutschland GmbH, 2023)
Purpose: This research study aims to determine the qualitative and quantitative common deficiencies included in the API section of dossiers submitted to SAHPRA. The study was conducted retrospectively over a 7-year period ...
Marburg virus disease amid Covid-19 in West Africa: An emerging and re-emerging zoonotic epidemic threat, future implications and way forward
(2023)
Amid the coronavirus 2019 (COVID-19) pandemic,
several African countries including Ghana
and Equatorial Guinea have reported several
zoonotic outbreaks. The COVID-19 pandemic
has added more strain on the already ...
Regulatory registration timelines of generic medicines in South Africa: Assessment of the performance of SAHPRA between 2011 and 2022
(Springer, 2023)
Various regulatory authorities are experiencing backlogs of applications which result in delayed access
to medicines for patients. The objective of this study is to critically assess the registration process utilised by ...