Research Articles (School of Pharmacy)

An assessment of social accountability among South African pharmacy schools from public domain information

Bheekie, Angeni; Van Huyssteen, Mea (AFAHPER-SD, 2017)

Global health education reform requires training institutions to align their education, service and research activities with the values of social accountability, which include relevance, equity, quality and effectiveness. ...

“I just kept quiet”: Exploring equity in a service-learning programme

Bheekie, Angeni; van Huyssteen, Mea; Rae, Nicolette; Swartbooi, Cindy (International Association for Research on Service-Learning and Community Engagement (IARSLCE), 2016)

Social justice underpins the sustainable development goal of health for all. In developing countries, social injustices are particularly severe and widespread, demanding critical and immediate attention. This article describes ...

Epidemiology and outcomes of Clostridium difficile infection among hospitalised patients: results of a multicentre retrospective study in South Africa

Legenza, Laurel; Barnett, Susanne; Rose, Warren; Bianchini, Monica; Safdar, Nasia (BMJ Publishing Group, 2018)

INTRODUCTION Limited data exist on Clostridium difficile infection (CDI) in low-resource settings and settings with high prevalence of HIV. We aimed to determine baseline CDI patient characteristics and management and ...

Re-engineering of South Africa’s primary health care system: where is the pharmacist?

Bheekie, Angeni; Bradley, Hazel A. (South African Academy of Family Physicians, 2016)

South Africa’s transition towards a district-based health system (DHS) aims to offer health promotion and prevention services at community level, through re-engineered primary health care (PHC) services. Along with pharmacy ...

Multi-targeted directed ligands for Alzheimer’s disease: design of novel lead coumarin conjugates

Repsold, B.P.; Malan, Sarel F.; Joubert, Jacques; Oliver, D.W. (Taylor & Francis, 2018)

Alzheimer’s Disease (AD) is a neurodegenerative disease characterized by central nervous system insults with progressive cognitive (memory, attention) and non-cognitive (anxiety, depression) impairments. Pathophysiological ...

Synthesis and biological evaluations of NO-donating oxa- and aza-pentacycloundecane derivatives as potential neuroprotective candidates

Sharma, Rajan; Joubert, Jacques; Malan, Sarel F. (MDPI, 2018)

In order to utilize the neuroprotective properties of polycyclic cage compounds, and explore the NO-donating ability of nitrophenyl groups, an array of compounds was synthesized where the different nitrophenyl groups ...

Pulmonary effects and disposition of luteolin and Artemisia afra extracts in isolated perfused lungs

Mjiqiza, Sizwe Joel; Syce, James Abraham; Obikeze, Kenechukwu (Elsevier, 2013)

ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia afra (Asteraceae) is a traditional medicinal plant frequently used in steam inhalation form to treat respiratory conditions. AIM OF THE STUDY: Quantify luteolin content in Artemisia ...

Evaluation of the antidiarrhoeal and antidiabetic activities of the leaf aqueous extract of Syzygium cordatum hoscht. ex C.Krauss (Mytraceae) in rodents

Deliwe, M.; Amabeoku, G.J. (Asian Network for Scientific Information, 2013)

Syzygium cordatum Hoscht. ex C.Krauss is widely used by traditional medicine practitioners to treat many ailments including diarrhoea and diabetes. Despite the folklore use, little evidence can be found in literature to ...

Involvement of gamma aminobutyric acid in the anticonvulsant effect of the leaf methanol extract of Ruta graveolens L. (Rutaceae) in mice

Ahmad, A.H.; Amabeoku, G.J. (Asian Network for Scientific Information, 2013)

The possible involvement of gamma aminobutyric acid (GABA), in the anticonvulsant effect of Ruta graveolens L. was investigated by studying the effect of the leaf methanol extract against seizures elicited by either ...

Small molecule efflux pump inhibitors in Mycobacterium tuberculosis: a rational drug design perspective

Kapp, Erika; Malan, Sarel F.; Joubert, Jacques; Sampson, Samantha L. (Bentham Science Publishers, 2018)

Drug resistance in Mycobacterium tuberculosis (M. tuberculosis) complicates management of tuberculosis. Efflux pumps contribute to low level resistance and acquisition of additional high level resistance mutations through ...

Microwave-assisted methods for the synthesis of pentacyclo[5.4.0.02,6.03,10.05,9]undecylamines

Joubert, Jacques; Sharma, Rajan; Onani, Martin O.; Malan, Sarel F. (Elsevier, 2013)

Efficient methodologies for the preparation of pentacyclo[5..4.0.02,6.03,10.05,9]undecane (PCU) amine derivatives are described via microwave-assisted synthesis. The obtained results revealed that microwave-assisted synthetic ...

3D-QSAR and docking studies of pentacycloundecylamines at the sigma-1 (σ1) receptor

Geldenhuys, Werner J.; Novotny, Nicholas; Malan, Sarel F.; Van der Schyf, Cornelis J. (Elsevier, 2013)

Pentacycloundecylamine (PCU) derived compounds have been shown to be promising lead structures for the development of novel drug candidates aimed at a variety of neurodegenerative and psychiatric diseases. Here we show for ...

What if students could be transformational resources for pharmacy practice?

Coetzee, Renier; Bheekie, Angeni; Van Huyssteen, Mea (Medpharm Publications, 2017)

The pharmacists’ role in the healthcare system is expanding internationally beyond the traditional roles of compounding and medicine supply management, to providing patientcentred care and updating health care workers ...

FTIR, dissolution and anti-viral activity of nevirapine co-crystals

Samsodien, Halima; Bapoo, Rafik; Doms, T.I.; Harneker, Z.; Louw, A.S.; Scheepers, I.C.; Sonday, A.B.; Geldenhuys, B. (OMICS International, 2017)

The study uses Fourier Transform Infrared (FTIR) spectroscopy to identify five Nevirapine (NV) co-crystals, determines the dissolution profile of the co-crystals and the antiviral activity comparative to pure NV. Hot ...

The hidden curriculum of work-based learning for pharmacy students in public sector pharmacies in South Africa

Van Huyssteen, Mea; Bheekie, Angeni (International Pharmaceutical Federation, 2017)

BACKGROUND: The work-based learning environment encompasses a dynamic space where the implementation of theoretical knowledge and skills may prove to be at odds with routine service delivery practices, known as the ...

Undergraduate antimicrobial stewardship training for pharmacy students: Creating a foundation for containment of antimicrobial resistance in South Africa

Khan, Y.; Boschmans, S.A.; McCartney, J.; Coetzee, R. (Health and Medical Publishing Group, 2017)

To the Editor: The inappropriate and excessive use of antimicrobial agents has cultivated the development and progression of antimicrobial resistance worldwide, which has been recognised as a threat to global health and ...

Reasons for missed appointments linked to a public-sector intervention targeting patients with stable chronic conditions in South Africa: results from in-depth interviews and a retrospective review of medical records

Magadzire, Bvudzai P.; Mathole, Thubelihle; Ward, Kim (BioMed Central, 2017)

BACKGROUND Missed appointments serve as a key indicator for adherence to therapy and as such, identifying patient reasons for this inconsistency could assist in developing programmes to improve health outcomes. In this ...