Browsing Research Articles (Biotechnology) by Title
Now showing items 55-74 of 215
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The determination of the effect(s) of solute carrier family 22‑member 2 (SLC22A2) haplotype variants on drug binding via molecular dynamic simulation systems
(Nature Research, 2022)Single nucleotide polymorphisms detected in the solute carrier member family-22 has been shown to result in a variable response in the treatment of type 2 diabetes mellitus with Metformin. This study predicted a ... -
Development of Effective Therapeutic Molecule from Natural Sources against Coronavirus Protease
(MDPI, 2021)Abstract: The SARS-CoV-2 main protease (Mpro) is one of the molecular targets for drug design. Effective vaccines have been identified as a long-term solution but the rate at which they are being administered is slow in ... -
Development of infectious transcripts and genome manipulation of black queen-cell virus of honey bees
(Microbiology Society, 2002)The South African isolate of Black queen-cell virus (BQCV), a honey bee virus, was previously found to have an 8550 nucleotide genome excluding the poly(A) tail. Its genome contained two ORFs, a 5«-proximal ORF encoding ... -
Diagnostic approaches of pneumonia for commercial-scale biomedical applications: An overview
(Taylor & Francis, 2020)Pneumonia remains the leading infectious cause of death among children under five years of age, and the elderly. Several biomarkers, which have been identified for its diagnosis lack specificity, as they could not ... -
Dietary effects of antimicrobial peptides in therapeutics
(Taylor & Francis, 2020-02-17)The notable increase in drug-resistant infections and the failure of the most potent antibiotics to establish their curative effect without side effect have presented a serious need for the discovery of new therapeutic ... -
Differentially expressed serum proteins from obese Wistar rats as a risk factor for obesity-induced diseases
(Springer Nature, 2020)Obesity is a chronic disease that negatively affects life expectancy through its association with life-threatening diseases such as cancer and cardiovascular diseases. Expression proteomics combined with in silico interaction ... -
Diversity of dsDNA viruses in a South African hot spring assessed by metagenomics and microscopy
(MDPI, 2017)The current view of virus diversity in terrestrial hot springs is limited to a few sampling sites. To expand our current understanding of hot spring viral community diversity, this study aimed to investigate the first ... -
DNA commission of the international society of forensic genetics (IGSF): recommendations on the interpretation of y-str results in forensic analysis
(Elsevier, 2020)Forensic genetic laboratories perform a large amount of STR analyses of the Y chromosome, in particular to analyze the male part of complex DNA mixtures. However, the statistical interpretation of evidence retrieved from ... -
Draft genome sequence of the putative endophytic bacterium pantoea agglomerans r6, associated with lactuca serriola from South Africa
(American Society for Microbiology, 2021)Here, we present the draft genome sequence (;4.7 Mb) of the endopyhtic bacterium Pantoea agglomerans strain R6, which was isolated from surface-sterilized roots of Lactuca serriola (prickly lettuce) -
Drought and exogenous abscisic acid alter hydrogen peroxide accumulation and diferentially regulate the expression of two maize RD22-like genes
(Nature Research, 2017)Increased biosynthesis of abscisic acid (ABA) occurs in plants in response to water defcit, which is mediated by changes in the levels of reactive oxygen species such as H2O2. Water defcit and ABA induce expression of ... -
Drought and salinity stress alters ROS accumulation, water retention, and osmolyte content in sorghum plants
(Elsevier, 2017)biotic stresses such as drought and salinity are major environmental factors that influence crop productivity worldwide. These adverse conditions induce osmotic stresses in plant cells by decreasing water availability, thus ... -
Effect of copper sulphate and cadmium chloride on non-human primate sperm function in vitro
(MDPI, 2021)Abstract: In order to address the large percentage of unexplained male infertility in humans, more detailed investigations using sperm functional tests are needed to identify possible causes for compromised fertility. Since ... -
Efficient superoxide scavenging and metal immobilization in roots determines the level of tolerance to vanadium stress in two contrasting Brassica napus genotypes
(Elsevier, 2018)Brassica napus also known as Rapeseed is a member of the Brassicaceae family which is mainly cultivated for its oil-rich seeds. Indeed, B. napus is ranked the third-largest source of vegetable oil in the world. Brassica ... -
Enhanced anti-bacterial activity of biogenic silver nanoparticles synthesized from terminalia mantaly extracts
(Dove Press, 2019)The global increase in outbreaks and mortality rates associated with multidrug- resistant (MDR) bacteria is a major health concern and calls for alternative treatments. Natural-derived products have shown potential in ... -
Enzymatic and proteomic exploration into the inhibitory activities of lemongrass and lemon essential oils against Botrytis cinerea (causative pathogen of gray mold)
(Frontiers Media, 2023)Essential oils (EOs) have been demonstrated as efficacious against B. cinerea. However, the underpinning enzymatic and proteomic mechanism for these inhibitory effects is not entirely clear. Thus, this study examined the ... -
Enzymatic and proteomic exploration into the inhibitory activities of lemongrass and lemon essential oils against botrytis cinerea (causative pathogen of gray mold)
(Front. Microbiol, 2023)Introduction: Essential oils (EOs) have been demonstrated as efficacious against B. cinerea. However, the underpinning enzymatic and proteomic mechanism for these inhibitory effects is not entirely clear. Methods: Thus, ... -
Establishing minion sequencing and genome assembly procedures for the analysis of the rooibos (aspalathus linearis) genome
(MDPI, 2022)While plant genome analysis is gaining speed worldwide, few plant genomes have been sequenced and analyzed on the African continent. Yet, this information holds the potential to transform diverse industries as it unlocks ... -
Ethical publication of research on genetics and genomics of biological material: guidelines and recommendations
(Elsevier, 2020)Forensic Science International: Genetics and Forensic Science International: Reports communicate research on a variety of biological materials using genetics and genomic methods. Numerous guidelines have been produced to ... -
Evaluation of selected carotenoids of Lycopersicon esculentum variants as therapeutic targets for 'Alzheimer's disease: an in silico approach BMC Molecular and Cell Biology
(Springer, 2021-10)The seriousness and menace of the worldwide weight of 'Alzheimer's disease have been related to a few factors, which incorporate antioxidant system depletion, mutation of proteins, and high expression of cholinesterases ... -
Evaluation of the morpho-physiological, biochemical and molecular responses of contrasting medicago truncatula lines under water deficit stress
(MPDI, 2021)Medicago truncatula is a forage crop of choice for farmers, and it is a model species for molecular research. The growth and development and subsequent yields are limited by water availability mainly in arid and semi-arid ...