Now showing items 1-6 of 6
Patient-Control Association Study of the Leucine-Rich Repeat Kinase 2 (LRRK2) Gene in South African Parkinson's Disease Patients
(National Institute of Health, 2013)
The leucine-rich repeat kinase 2 (LRRK2) gene is of interest to Parkinson's disease (PD) as it has been implicated in both familial and sporadic forms of the disorder.1 PD-susceptibility alleles in LRRK2 appear to be ...
Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease
(Oxford University Press, 2013)
BACKGROUND. The development of active tuberculosis disease has been shown to be multifactorial. Interactions between host and bacterial genotype may influence disease outcome, with some studies indicating the adaptation ...
BDNF Val66Met modifies the risk of childhood trauma on obsessive-compulsive disorder
Childhood trauma has been linked to the development of later psychopathology, including obsessive-compulsive disorder (OCD). Although evidence exists to suggest that genetic and environmental factors are involved in the ...
BDNF Val66Met and DRD2 Taq1A polymorphisms interact to influence PTSD symptom severity: A preliminary investigation in a South African population
BACKGROUND: We evaluated the role that selected variants in serotonin transporter (5-HTT), dopamine receptor 2 (DRD2) and brain-derived neurotrophic factor (BDNF) genes play in PTSD symptom severity in an at-risk population. ...
A Panel of Ancestry Informative Markers for the Complex Five-Way Admixed South African Coloured Population
Admixture is a well known confounder in genetic association studies. If genome-wide data is not available, as would be the case for candidate gene studies, ancestry informative markers (AIMs) are required in order to adjust ...
Association between pro-inflammatory alleles and allergic phenotypes in Xhosa adolescents
BACKGROUND: Significant differences exist in the prevalence, spectrum, and severity of allergic diseases between developing and developed countries and between subpopulations within single countries. These discrepancies ...