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Human African trypanosomiasis research gets booost: unravelling the tsetse Genome
(PLOS, 2014)
Human African trypanosomiasis (HAT), also known as sleeping sickness, is a neglected disease that impacts 70 million people distributed over 1.55 million km2 in sub-Saharan Africa. Trypanosoma brucei gambiense accounts for ...
HIV-1 diversity and the implementation of integrase strand-transfer inhibitors as part of combination antiretroviral therapy
(SAMA, 2020)
: The integrase (IN) strand-transfer inhibitor (InSTI)
dolutegravir (DTG) is now recommended by the World Health
Organization as part of salvage and/or first-line combination
antiretroviral therapy (cART).[1] DTG has a ...
Designing a course model for distance-based online bioinformatics training in Africa: the H3ABioNet experience
(Public Library of Science, 2017)
Africa is not unique in its need for basic bioinformatics training for individuals from a diverse
range of academic backgrounds. However, particular logistical challenges in Africa, most
notably access to bioinformatics ...
Multistage antiplasmodial activity of hydroxyethylamine compounds,in vitroandin vivoevaluations
(Royal Society of Chemistry, 2020)
Malaria, a global threat to the human population, remains a challenge partly due to the fast-growing drug-resistant strains of Plasmodium species. New therapeutics acting against the pathogenic asexual and sexual stages, ...
Capacity building for whole genome sequencing of Mycobacterium tuberculosis and bioinformatics in high TB burden countries
(Oxford University Press, 2020)
Background
Whole-genome sequencing (WGS) is increasingly used for Mycobacterium tuberculosis (Mtb) research. Countries with the highest tuberculosis (TB) burden face important challenges to integrate WGS into surveillance ...
A view on genomic medicine activities in Africa: Implications for policy
(Frontiers Media, 2022)
Genomics policy development involves assessing a wide range of issues extending from
specimen collection and data sharing to whether and howto utilize advanced technologies in
clinical practice and public health initiatives. ...
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
(American Association for the Advancement of Science, 2022)
Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing in Africa over the past year has led to a major increase in the number of sequences that have been generated and used to track the ...
Prioritization of anti-malarial hits from nature: Chemo-informatic profiling of natural products with in vitro antiplasmodial activities and currently registered anti-malarial drugs
(BMC, 2016)
A large number of natural products have shown in vitro antiplasmodial activities. Early identification
and prioritization of these natural products with potential for novel mechanism of action, desirable pharmacokinetics ...
Changes in subcutaneous adipose tissue microRNA expression in response to exercise training in African women with obesity
(Nature Research, 2022)
The mechanisms that underlie exercise-induced adaptations in adipose tissue have not been
elucidated, yet, accumulating studies suggest an important role for microRNAs (miRNAs). This study
aimed to investigate miRNA ...