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Human Leukocyte Antigen-A, B, C, DRB1, and DQB1 Allele and Haplotype Frequencies in a subset of 237 donors in the South African Bone Marrow Registry
(Hindawi, 2018)
Human leukocyte antigen- (HLA-) A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 allele and haplotype frequencies were studied in a subset of 237 volunteer bone marrow donors registered at the South African Bone Marrow Registry ...
Defining the molecular signatures of Achilles tendinopathy and anterior cruciate ligament ruptures: A whole-exome sequencing approach
(Public Library of Science, 2018)
Musculoskeletal soft tissue injuries are complex phenotypes with genetics being one of
many proposed risk factors. Case-control association studies using the candidate gene
approach have predominately been used to identify ...
The westward journey of alfalfa leaf curl virus
(MDPI, 2018)
Alfalfa leaf curl virus (ALCV), which causes severe disease symptoms in alfalfa (Medicago
sativa L.) and is transmitted by the widespread aphid species, Aphis craccivora Koch, has been
found throughout the Mediterranean ...
Geometagenomics illuminates the impact of agriculture on the distribution and prevalence of plant viruses at the ecosystem scale
(Nature Publishing Group, 2018)
Disease emergence events regularly result from human activities such as agriculture, which
frequently brings large populations of genetically uniform hosts into contact with potential
pathogens. Although viruses cause ...
Structural rearrangements maintain the Glycan Shield of an HIV-1 envelope trimer after the loss of a glycan
(Nature Research, 2018)
The HIV-1 envelope (Env) glycoprotein is the primary target of the humoral immune response and a
critical vaccine candidate. However, Env is densely glycosylated and thereby substantially protected
from neutralisation. ...
Predictive classifier models built from natural products with antimalarial bioactivity using machine learning approach
(Public Library of Science, 2018)
In view of the vast number of natural products with potential antiplasmodial bioactivity
and cost of conducting antiplasmodial bioactivity assays, it may be judicious to learn from
previous antiplasmodial bioassays and ...
Developing reproducible bioinformatics analysis workflows for heterogeneous computing environments to support African genomics
(Springer Nature, 2018)
Background: The Pan-African bioinformatics network, H3ABioNet, comprises 27 research institutions in 17 African
countries. H3ABioNet is part of the Human Health and Heredity in Africa program (H3Africa), an African-led ...
Exome sequencing identifies novel dysferlin mutation in a family with pauci-symptomatic heterozygous carriers
(Springer Nature, 2018)
Background: We investigated a South African family of admixed ancestry in which the first generation (G1) developed
insidious progressive distal to proximal weakness in their twenties, while their offspring (G2) experienced ...
Exome sequencing identifies novel dysferlin mutation in a family with paucisymptomatic heterozygous carriers
(BioMed Central, 2018)
BACKGROUND: We investigated a South African family of admixed ancestry in which the first generation (G1) developed
insidious progressive distal to proximal weakness in their twenties, while their offspring (G2) experienced ...
Cross-species multiple environmental stress responses: An integrated approach to identify candidate genes for multiple stress tolerance in sorghum (Sorghum bicolor (L.) Moench) and related model species
(Public Library of Science, 2018)
BACKGROUND
Crop response to the changing climate and unpredictable effects of global warming with
adverse conditions such as drought stress has brought concerns about food security to the
fore; crop yield loss is a major ...