Search
Now showing items 1-6 of 6
Developing reproducible bioinformatics analysis workflows for heterogeneous computing environments to support African genomics
(Springer Nature, 2018)
Background: The Pan-African bioinformatics network, H3ABioNet, comprises 27 research institutions in 17 African
countries. H3ABioNet is part of the Human Health and Heredity in Africa program (H3Africa), an African-led ...
Prediction of human-Bacillus anthracis protein–protein interactions using multi-layer neural network
(Oxford University Press, 2018)
Triplet amino acids have successfully been included in feature selection to predict
human-HPV protein-protein interactions (PPI). The utility of supervised learning methods is
curtailed due to experimental data not being ...
Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies
(Springer Nature, 2015)
The coronavirus 3 chymotrypsin-like protease (3CLpro) is a validated target in the design of potential
anticoronavirus inhibitors. The high degree of homology within the protease’s active site and substrate conservation
supports ...
Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery
(BMC, 2014)
We have recently shown by formally modelling human protein interaction networks (PINs) as metric
spaces and classified proteins into zones based on their distance from the topological centre that hub proteins are
primarily ...
Semantic interrogation of a multi knowledge domain ontological model of tendinopathy identifies four strong candidate risk genes
(Nature Research, 2016)
Tendinopathy is a multifactorial syndrome characterised by tendon pain and thickening, and impaired
performance during activity. Candidate gene association studies have identified genetic factors
that contribute to ...
Computational characterization of iron metabolism in the tsetse disease vector, glossina morsitans: Ire stem-loops
(BMC, 2016)
Iron metabolism and regulation is an indispensable part of species survival, most importantly for
blood feeding insects. Iron regulatory proteins are central regulators of iron homeostasis, whose binding to iron
response ...