Search
Now showing items 1-10 of 21
Conceptualising COVID-19’s impacts on household food security
(Springer, 2020)
COVID-19 undermines food security both directly, by disrupting food systems, and indirectly, through the impacts of lockdowns
on household incomes and physical access to food. COVID-19 and responses to the pandemic could ...
HIV-1 diversity and the implementation of integrase strand-transfer inhibitors as part of combination antiretroviral therapy
(SAMA, 2020)
: The integrase (IN) strand-transfer inhibitor (InSTI)
dolutegravir (DTG) is now recommended by the World Health
Organization as part of salvage and/or first-line combination
antiretroviral therapy (cART).[1] DTG has a ...
Modelling the impact of maternal HIV on uninfected children: correcting current estimates
(Taylor & Francis, 2020)
A mathematical model, populated primarily with data from South Africa, was developed to model the numbers of children affected by maternal HIV, and the number who will experience long-term negative developmental consequences. ...
Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C integrase-dolutegravir binding
(Public Library of Science, 2020)
Resistance associated mutations (RAMs) threaten the long-term success of combination antiretroviral therapy (cART) outcomes for HIV-1 treatment. HIV-1 Integrase (IN) strand transfer inhibitors (INSTIs) have proven to be a ...
Structural comparison of diverse HIV-1 subtypes using molecular modelling and docking analyses of integrase inhibitors
(MPDI, 2020)
The process of viral integration into the host genome is an essential step of the HIV-1 life cycle. The viral integrase (IN) enzyme catalyzes integration. IN is an ideal therapeutic enzyme targeted by several drugs; ...
Multistage antiplasmodial activity of hydroxyethylamine compounds,in vitroandin vivoevaluations
(Royal Society of Chemistry, 2020)
Malaria, a global threat to the human population, remains a challenge partly due to the fast-growing drug-resistant strains of Plasmodium species. New therapeutics acting against the pathogenic asexual and sexual stages, ...
Diverse genomoviruses representing twenty-nine species identified associated with plants
(Springer Nature, 2020)
Genomoviruses (family Genomoviridae) are circular single-stranded DNA viruses that have been mainly identifed through
metagenomics studies in a wide variety of samples from various environments. Here, we describe 98 genomes ...
Inhibiting CDK6 activity by quercetin is an attractive strategy for cancer therapy
(American Chemical Society, 2020)
Cyclin-dependent kinase 6 (CDK6) is a potential drug target that plays an important role in the progression of different types of cancers. We performed in silico and in vitro screening of different natural compounds and ...
Careful governance of African biobanks
(Elsevier, 2020)
The Sydney Statement is one of
the first framing documents on the
principles for guiding global health
security. Framing matters because
the funding pool for development
assistance for health is finite and has
plateaued ...
Drug resistance mutations against protease, reverse transcriptase and integrase inhibitors in people living with HIV-1 receiving boosted protease inhibitors in South Africa
(Frontiers Media S.A., 2020)
The South African national combination antiretroviral therapy (cART) roll-out program started in 2006, with over 4.4 million people accessing treatment since it was first introduced. HIV-1 drug resistance can hamper the ...