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Antimycobacterial Activity, Synergism, and Mechanism of Action Evaluation of Novel Polycyclic Amines against Mycobacterium tuberculosis
(Advances in Pharmacological and Pharmaceutical Sciences, 2021-06)
Mycobacterium tuberculosis has developed extensive resistance to numerous antimycobacterial agents used in the treatment of tuberculosis. Insufficient intracellular accumulation of active moieties allows for selective ...
Discovery of 9-phenylacridinediones as highly selective butyrylcholinesterase inhibitors through structure-based virtual screening
(Elsevier, 2020)
Butyrylcholinesterase (BuChE) is considered a promising drug target as it plays an important role in the pro-gression of late stage Alzheimer’s disease (AD). Two compound libraries were selected and 64 124 aminecontaining ...
Cashew nut testa tannin resin – preparation, characterization and adsorption studies
(Journal of Taibah University for Science, 2021-06)
Adsorption of metal ions and dyes from water by cashew nut testa tannin resin (CATAR) was studied and the effects of temperature, initial pH, initial concentration and time were investigated. Scanning electron microscopy ...
Common defciencies found in generic Finished Pharmaceutical Product (FPP) applications submitted for registration to the South African Health Products Regulatory Authority (SAHPRA)
(Springer Nature, 2022)
The aim of the study was to investigate the common defciencies observed in the Finished Pharmaceutical Product (FPP) section of generic product applications submitted to SAHPRA. The study was conducted
retrospectively ...
Venous thromboembolism risk assessment and prophylaxis in hospitalised medical patients in the Cape Town metropole, South Africa
(South African Medical Association, 2022)
Venous thromboembolism (VTE) is regarded as the most preventable cause of inpatient death in hospital settings globally. VTE can be prevented through the provision of non-pharmacological and/or pharmacological thromboprophylaxis ...
Parental reporting of adverse drug reactions in South Africa: An online survey
(AOSIS, 2021)
The high incidence of adverse drug reactions (ADRs) in children is of global
concern. Enhancing the reporting of ADRs could contribute to making safer medicines
available to children.To assess parents’ awareness of ...
Medicines regulatory science expertise in Africa: workforce capacity development and harmonisation activities towards the establishment of the African medicines agency
(Adis, 2022)
The medicines regulatory landscape in Africa is undergoing transformation with at least two countries having National Medicines Regulatory Authorities (NRAs) that operate at World Health Organization (WHO) maturity level ...
Pharmacists’ approach to optimise safe medication use in paediatric patients
(MPDI, 2021)
Paediatric patients are unique, yet challenging patients to care for by pharmacists. Paediatric medicine use requires special consideration. Pharmacists play an important role in educating and counselling patients, carers, ...
Continuous professional development for public sector pharmacists in South Africa: A case study of mapping competencies in a pharmacists’ preceptor programme
(MPDI, 2020)
Lifelong learning among healthcare practitioners is crucial to keep abreast of advances in
therapeutic and service delivery approaches. In South Africa, continuous professional development
(CPD) was mandated (2019) for ...
Establishing a pharmacist–prescriber partnership in publicly funded primary healthcare clinics to optimise antibiotic prescribing in the Western Cape: An exploratory study
(AOSIS, 2020)
Promoting evidence-based antibiotic prescribing through successful antimicrobial
stewardship (AMS) programmes is critical to preserving the effectiveness of antibiotics for
common infections in primary care. This requires ...