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Synthesis of 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as lead scaffolds for neuroprotective agents
(Arkivoc, 2020-09)
Neurodegenerative disorders are characterised by progressive loss of neuronal functions. Of the proposed mechanisms, excitotoxicity, mediated by prolonged glutamate activation and calcium overload, is prominent. NGP1-01, ...
Synthesis of 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as lead scaffolds for neuroprotective agents
(Arkivoc, 2020-09)
Neurodegenerative disorders are characterised by progressive loss of neuronal functions. Of the proposed mechanisms, excitotoxicity, mediated by prolonged glutamate activation and calcium overload, is prominent. NGP1-01, ...
Pharmaceutical co-crystal: An alternative strategy for enhanced physicochemical properties and drug synergy
(Wiley Open Access, 2020)
A growing number of co-crystals in the literature are proof of how significant
the co-crystallization concept has become. Co-crystallization enhances
physicochemical properties through the formation of intermolecular ...
Polymer-based protein delivery systems for loco-regional administration
(Taylor and Francis Group, 2021)
With the advent of recombinant technology, a wide variety of biocompatible therapeutic proteins can be produced with relative ease. These proteins are formulated and subsequently administered in patients to treat various ...
Synthesis of 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as lead scaffolds for neuroprotective agents
(ARKAT USA, 2020)
Neurodegenerative disorders are characterised by progressive loss of neuronal functions. Of the proposed mechanisms, excitotoxicity, mediated by prolonged glutamate activation and calcium overload, is prominent. NGP1-01, ...
Cheminformatic profiling and hit prioritization of natural products with activities against Methicillin-Resistant Staphylococcus Aureus (MRSA)
(MPDI, 2021)
Several natural products (NPs) have displayed varying in vitro activities against methicillinresistant Staphylococcus aureus (MRSA). However, few of these compounds have not been developed
into potential antimicrobial ...
Marburg virus disease outbreak amidst COVID-19 in the Republic of Guinea: A point of contention for the fragile health system?
(Elsevier, 2022)
In August 2021, the Marburg virus disease (MVD) outbreak was confirmed amid the coronavirus disease 2019
(COVID-19) pandemic in the Republic of Guinea. This is the first time it is detected in Guinea and West Africa.
Marburg ...
Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer’s disease agents
(Taylor & Francis Open Access, 2021)
Multitarget directed ligands (MTDLs) are emerging as promising treatment options for Alzheimer’s disease
(AD). Coumarin derivatives serve as a good starting point for designing MTDLs due to their inherent inhibition of ...
Cheminformatic Profiling and Hit Prioritization of Natural Products with Activities against Methicillin-Resistant Staphylococcus aureus (MRSA)
(Molecules, 2021-06)
Several natural products (NPs) have displayed varying in vitro activities against methicillin-resistant Staphylococcus aureus (MRSA). However, few of these compounds have not been developed into potential antimicrobial ...
Development and implementation of an integrated framework for undergraduate pharmacy training in maternal and child health at a South African university
(MPDI, 2021)
The South African Pharmacy Council (SAPC) regulates undergraduate pharmacy education
and pharmacy practice. The SAPC Good Pharmacy Practice manual describes the role of pharmacists
in maternal and child health (MCH) in ...