Research Articles (School of Pharmacy): Recent submissions
Now showing items 81-100 of 151
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Pharmaceutical co-crystal: An alternative strategy for enhanced physicochemical properties and drug synergy
(Wiley Open Access, 2020)A growing number of co-crystals in the literature are proof of how significant the co-crystallization concept has become. Co-crystallization enhances physicochemical properties through the formation of intermolecular ... -
Evaluation of Antibacterial Activity of Bryopsis pennata and Chaetomorpha antennina against Multidrug Resistant Morganella morganii and Salmonella species Isolated from Healthy Individuals
(International Journal for Pharmaceutical Research Scholars, 2017)The problem of antibiotic resistance is fast becoming a pandemic which has necessitated the need for new drugs discovery. This study was carried out to screen two green algal species- Bryopsis pennata and Chaetomorpha ... -
The effectiveness of using text and pictograms on oral rehydration, dry-mixture sachet labels
(AOSIS, 2021)Medication labels are often the only information available to patients after obtaining medication from a healthcare practitioner. Pictograms are graphic symbols that have shown to increase understanding of medicine use ... -
4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potential
(MDPI, 2020)The impact of excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptor overactivation and voltage gated calcium channel (VGCC) depolarization is prominent among the postulated processes involved in the development ... -
Antibacterial Activities of Selected Green Seaweeds from West African Coast
(EC Pharmacology and Toxicology ECronicon Open Access, 2020)The continually increasing antibiotic resistance amongst microorganisms had steered up an increased intensity in the search for new drugs. The marine environment had been reported to be a great source of novel compounds ... -
Curdlan–chitosan electrospun fibers as potential scaffolds for bone regeneration
(MPDI, 2021)Polysaccharides have received a lot of attention in biomedical research for their high potential as scaffolds owing to their unique biological properties. Fibrillar scaffolds made of chitosan demonstrated high promise in ... -
Application of fundamental techniques for physicochemical characterizations to understand post-formulation performance of pharmaceutical nanocrystalline materials
(MPDI, 2021)Nanocrystalline materials (NCM, i.e., crystalline nanoparticles) have become an important class of materials with great potential for applications ranging from drug delivery and electronics to optics. Drug nanocrystals ... -
Physicochemical stability of enriched phenolic fractions of cyclopia genistoides and ex vivo bi-directional permeability of major xanthones and benzophenones
(Georg Thieme Verlag, 2021)Fractions of an ultrafiltered Cyclopia genistoides extract, respectively enriched in xanthones and benzophenones, were previously shown to inhibit mammalian α -glucosidase in vitro. The present study investigated ex vivo ... -
A qualitative meta-synthesis of facilitators and barriers to tuberculosis diagnosis and treatment in Nigeria
(Springer Nature, 2021): Despite progress in tuberculosis (TB) control globally, TB continues to be a leading cause of death from infectious diseases, claiming 1.2 million lives in 2018; 214,000 of these deaths were due to drug resistant strains. ... -
Access to chronic medicines: patients’ preferences for a last kilometre medicine delivery service in Cape Town, South Africa
(Springer Nature, 2021): Chronic patients are required to access their chronic medicines on a regular basis, often only to refill their repeat prescriptions. Adherence to chronic medicines is challenging and has stimulated health care providers to ... -
Evaluating pharmacy students’ knowledge and skills in reproductive, maternal, new-born and child health care at a South African university
(Springer Nature, 2021)Maternal and child mortality is a global concern and one of South Africa’s quadruple burdens of disease. As easily accessible frontline healthcare workers, pharmacists play an important role in the continuum of maternal ... -
Establishment of the African Medicines Agency: Progress, challenges and regulatory readiness
(Springer Nature, 2021)Insufcient access to quality, safe, efcacious and afordable medical products in Africa has posed a signifcant challenge to public health for decades. In part, this is attributed to weak or absent policies and regulatory ... -
Synthesis of 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as lead scaffolds for neuroprotective agents
(Arkat USA, 2020)Neurodegenerative disorders are characterised by progressive loss of neuronal functions. Of the proposed mechanisms, excitotoxicity, mediated by prolonged glutamate activation and calcium overload, is prominent. NGP1-01, ... -
4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as nmda receptor- And VGCC blockers with neuroprotective potential
(MPDI, 2020)The impact of excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptor overactivation and voltage gated calcium channel (VGCC) depolarization is prominent among the postulated processes involved in the development ... -
Mechanochemical synthesis and physicochemical characterization of isoniazid and pyrazinamide co-crystals with Glutaric acid
(Frontiers Media S.A., 2020)The present work reports two novel pharmaceutical co-crystals; 2:1 isoniazid-glutaric acid (INHGA) and 2:1 pyrazinamide-glutaric acid (PGA). Isoniazid and pyrazinamide are key first-line drugs used for the treatment of ... -
Encapsulation of variabilin in stearic acid solid lipid nanoparticles enhances its anticancer activity in vitro
(MDPI, 2020)The use of natural products as chemotherapeutic agents is well established; however, many of these are associated with undesirable side effects, including high toxicity and instability. Furthermore, the development of drug ... -
Amitriptyline prescribing in public sector healthcare facilities in the Western Cape, South Africa
(Public Library of Science, 2020)Inappropriate medication use is a major patient safety concern, especially for the elderly population. Amitriptyline is widely used in primary care in South Africa and a cross-sectional study found that amitriptyline was ... -
Development of a method to determine the cost of breast cancer treatment with chemotherapy at Groote Schuur Hospital, Cape Town, South Africa
(SAMA, 2020)There has been no comprehensive study determining the financial burden of breast cancer in the South African (SA) public sector. Objectives. To develop a method to determine the cost of breast cancer treatment with ... -
Establishing a pharmacist–prescriber partnership in publicly funded primary healthcare clinics to optimisantibiotic prescribing in the Western Cape: An exploratory study
(Taylor & Francis, 2020)Promoting evidence-based antibiotic prescribing through successful antimicrobial stewardship (AMS) programmes is critical to preserving the effectiveness of antibiotics for common infections in primary care. This requires ... -
A retrospective descriptive investigation of adult patients receiving third-line antiretroviral therapy in the North West province, South Africa
(Makerere University, 2020)Greater access and prolonged exposure to ART may inevitably lead to more treatment failure and increase the need for third-line ART (TLART) in a resource-limited setting. Objective: To describe characteristics and resistance ...