Browsing Research Articles (Biotechnology) by Title
Now showing items 41-60 of 215
-
Common bean as a potential crop for future food security: an overview of past, current and future contributions in genomics, transcriptomics, transgenics and proteomics
(Taylor & Francis Open Access, 2021)Common bean is an important legume crop having high quality protein, micronutrients, vitamins and antioxidants, which makes it a “grain of hope” for poor communities. Hence, a good number of breeding activities have been ... -
Comparative analysis of responses to field salinity stress in contrasting soybean accessions highlights NaCl exclusion in leaves as a key mechanism for salinity stress tolerance.
(JOURNAL OF OASIS AGRICULTURE AND SUSTAINABLE DEVELOPMENT, 2021)Salinity is one of the main limitations to legume productivity in many regions of the world and it is estimated that 50% of all arable land will become affected by salinity by 2050. The impact of field salinity on soybean ... -
Comparative proteomics analysis between maize and sorghum uncovers important proteins and metabolic pathways mediating drought tolerance
(MDPI, 2023)Drought severely affects crop yield and yield stability. Maize and sorghum are major crops in Africa and globally, and both are negatively impacted by drought. However, sorghum has a better ability to withstand drought ... -
Comparative venom toxin analyses of Nigerian viperidae and elapidae snakes
(Elsevier, 2023)Envenoming by snakebite is a serious health problem that maims and kills a large number of people, primarily in rural areas of developing African countries. The first comparative venom proteomic analyses of four snakes ... -
Comparative whole corona fingerprinting and protein adsorption thermodynamics of PLGA and PCL nanoparticles in human serum
(Elsevier, 2020)Nanoparticles (NPs) based on biocompatible and biodegradable polymers such as poly(lactic-co-glycolic acid) (PLGA) and polycaprolactone (PCL) represent effective systems for systemic drug delivery. Upon injection into the ... -
Computational and preclinical prediction of the antimicrobial properties of an agent isolated from monodora myristica: A novel dna gyrase inhibitor
(MDPI, 2023)The African nutmeg (Monodora myristica) is a medically useful plant. We, herein, aimed to critically examine whether bioactive compounds identified in the extracted oil of Monodora myristica could act as antimicrobial ... -
Computational insight of dexamethasone against potential targets of SARS-CoV-2
(Taylor and Francis Group, 2022)The health sector has been on the race to find a potent therapy for coronavirus disease (COVID)-19, a diseases caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2. Repurposed anti-viral drugs have played ... -
Crispr-based multi-gene integration strategies to create saccharomyces cerevisiae strains for consolidated bioprocessing
(MDPI, 2022)Significant engineering of Saccharomyces cerevisiae is required to enable consolidated bioprocessing (CBP) of lignocellulose to ethanol. Genome modification in S. cerevisiae has been successful partly due to its efficient ... -
Cross-sectional study of prevalence and determinants of uncontrolled hypertension among South African adult residents of Mkhondo municipality
(Springer Nature, 2020)Achieving the blood pressure treatment target in individuals with hypertension is a serious global health challenge. Furthermore, the actual burden of uncontrolled hypertension is poorly understood, especially in the ... -
Cross-sectional study of the association of 5 single nucleotide polymorphisms with enalapril treatment response among South African adults with hypertension
(NLM (Medline), 2021-11-19)This study investigates the association of 5 single nucleotide polymorphisms (SNPs) in selected genes (ABO, VEGFA, BDKRB2, NOS3, and ADRB2) with blood pressure (BP) response to enalapril. The study further assessed genetic ... -
A decade of plant proteomics and mass spectrometry: Translation of technical advancements to food security and safety issues
(Wiley, 2013)Tremendous progress in plant proteomics driven by mass spectrometry (MS) techniques has been made since 2000 when few proteomics reports were published and plant proteomics was in its infancy. These achievements include ... -
Decoding heavy metal stress signalling in plants: Towards improved food security and safety
(MDPI, 2020)The mining of heavy metals from the environment leads to an increase in soil pollution, leading to the uptake of heavy metals into plant tissue. The build-up of toxic metals in plant cells often leads to cellular damage ... -
Degradation of hydrocarbons and heavy metal reduction by marine bacteria in highly contaminated sediments
(MDPI, 2020)Investigations on the ability of bacteria to enhance removal of hydrocarbons and reduce heavy metal toxicity in sediments are necessary to design more effective bioremediation strategies. In this study, five bacterial ... -
Design and synthesis of acyldepsipeptide-1 analogues: antibacterial activity and cytotoxicity screening
(Arabian Journal of Chemistry, 2023)Acyldepsipeptides (ADEPs) are receiving more attention as prospective antimicrobial agents due to their unique mode of action and chemical properties. However, their therapeutic potential is limited by their poor pharmacokinetic ... -
The determination of the effect(s) of solute carrier family 22‑member 2 (SLC22A2) haplotype variants on drug binding via molecular dynamic simulation systems
(Nature Research, 2022)Single nucleotide polymorphisms detected in the solute carrier member family-22 has been shown to result in a variable response in the treatment of type 2 diabetes mellitus with Metformin. This study predicted a ... -
Development of Effective Therapeutic Molecule from Natural Sources against Coronavirus Protease
(MDPI, 2021)Abstract: The SARS-CoV-2 main protease (Mpro) is one of the molecular targets for drug design. Effective vaccines have been identified as a long-term solution but the rate at which they are being administered is slow in ... -
Development of infectious transcripts and genome manipulation of black queen-cell virus of honey bees
(Microbiology Society, 2002)The South African isolate of Black queen-cell virus (BQCV), a honey bee virus, was previously found to have an 8550 nucleotide genome excluding the poly(A) tail. Its genome contained two ORFs, a 5«-proximal ORF encoding ... -
Diagnostic approaches of pneumonia for commercial-scale biomedical applications: An overview
(Taylor & Francis, 2020)Pneumonia remains the leading infectious cause of death among children under five years of age, and the elderly. Several biomarkers, which have been identified for its diagnosis lack specificity, as they could not ... -
Dietary effects of antimicrobial peptides in therapeutics
(Taylor & Francis, 2020-02-17)The notable increase in drug-resistant infections and the failure of the most potent antibiotics to establish their curative effect without side effect have presented a serious need for the discovery of new therapeutic ... -
Differentially expressed serum proteins from obese Wistar rats as a risk factor for obesity-induced diseases
(Springer Nature, 2020)Obesity is a chronic disease that negatively affects life expectancy through its association with life-threatening diseases such as cancer and cardiovascular diseases. Expression proteomics combined with in silico interaction ...