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MicroRNA-based regulation of Aurora A kinase in breast cancer
(Impact Journals, 2020)
The involvement of non-coding RNAs (ncRNAs) in cellular physiology and disease pathogenesis is becoming increasingly relevant in recent years specifically in cancer research. Breast cancer (BC) has become a health concern ...
Gold nanoparticles synthesized using extracts of cyclopia intermedia, commonly known as honeybush, amplify the cytotoxic effects of doxorubicin
(MPDI, 2021)
Cyclopia intermedia (C. intermedia) is an indigenous South African shrub used to prepare the popular medicinal honeybush (HB) tea. This plant contains high levels of mangiferin (MGF), a xanthonoid that was reported to have ...
Gene expression alterations and molecular analysis of CHEK1 in solid tumors
(MDPI, 2020)
Alterations in the Checkpoint kinase (CHEK1) gene, its regulation, and the possible clinical outcomes in human solid tumors have not been previously examined. Therefore, the present study was carried out to evaluate the ...
Immunoinformatics design of a novel epitope-based vaccine candidate against dengue virus
(Springer, 2021-10)
Dengue poses a global health threat, which will persist without therapeutic intervention. Immunity induced by exposure to one serotype does not confer long-term protection against secondary infection with other serotypes ...
Green synthesis of metallic nanoparticles using some selected medicinal plants from southern africa and their biological applications
(MDPI, 2021)
The application of metallic nanoparticles (MNPs), especially that of silver, gold, cobalt, and zinc as antimicrobial, anticancer, drug delivery, contrast, and bioimaging agents has transformed the field of medicine. Their ...
Development of Effective Therapeutic Molecule from Natural Sources against Coronavirus Protease
(MDPI, 2021)
Abstract: The SARS-CoV-2 main protease (Mpro) is one of the molecular targets for drug design. Effective vaccines have been identified as a long-term solution but the rate at which they are being administered is slow in ...
Understanding the epidemiology, pathophysiology, diagnosis and management of SARS-CoV-2
(SAGE, 2020)
The emergence of coronavirus disease 2019 (COVID-19) in December 2019 has resulted in over 20 million cases and 741,808 deaths globally, affecting more than 200 countries. COVID-19 was declared a pandemic on 11 March 2020 ...
Differentially expressed serum proteins from obese Wistar rats as a risk factor for obesity-induced diseases
(Springer Nature, 2020)
Obesity is a chronic disease that negatively affects life expectancy through its association with life-threatening diseases such as cancer and cardiovascular diseases. Expression proteomics combined with in silico interaction ...
Synthesis of biogenic gold nanoparticles from terminalia mantaly extracts and the evaluation of their in vitro cytotoxic effects in cancer cells
(MDPI, 202-09-12)
Scientists have demonstrated the potential of plant materials as 'green' reducing and stabilizing agents for the synthesis of gold nanoparticles (AuNPs) and opened new ecofriendly horizons to develop effective and less ...
Aptamer-Based Diagnostic Systems for the Rapid Screening of TB at the Point-of-Care
(MDPI, 2021)
The transmission of Tuberculosis (TB) is very rapid and the burden it places on health care systems is felt globally. The effective management and prevention of this disease requires that it is detected early. Current TB ...