Genomic association of single nucleotide polymorphisms with blood pressure response to hydrochlorothiazide among south african adults with hypertension
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Date
2020Author
Masilela, Charity Mandisa
Pearce, Brendon
Ongole, Joven Jebio
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: This study described single nucleotide polymorphisms (SNPs) in hydrochlorothiazideassociated genes and further assessed their correlation with blood pressure control among South
African adults living with hypertension. A total of 291 participants belonging to the Nguni tribes of
South Africa on treatment for hypertension were recruited. Nineteen SNPs in hydrochlorothiazide
pharmacogenes were selected and genotyped using MassArray. Uncontrolled hypertension was
defined as blood pressure ≥140/90 mmHg. The association between genotypes, alleles and blood
pressure response to treatment was determined by conducting multivariate logistic regression model
analysis. The majority of the study participants were female (73.19%), Xhosa (54.98%) and had blood
pressure ≥140/90 mmHg (68.73%). Seventeen SNPs were observed among the Xhosa tribe, and two
(rs2070744 and rs7297610) were detected among Swati and Zulu participants.