Genetic lesions within the 3a gene of SARS-CoV
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Date
2005Author
Tan, Timothy H.P.
Barkham, Timothy
Fielding, Burtram C.
Chou, Chih-Fong
Shen, Shuo
Lim, Seng Gee
Hong, Wanjin
Tan, Yee-Joo
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A series of frameshift mutations within the 3a gene has been observed in culture-derived severe
acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical
samples obtained from SARS-CoV infected patients also contains a heterogeneous population of
wild-type and mutant 3a transcripts.