Browsing Medical Bioscience by Issue Date
Now showing items 141-160 of 277
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Do lifestyle practices impede male fertility?
(John Wiley & Sons, Inc, 2020)Alongside an increasing prevalence of couple and male infertility, evidence suggests there is a global declining trend in male fertility parameters over the past few decades. This may, at least in part, be explained ... -
Are claudin-5 tight-junction proteins in the blood-brain barrier porous?
(Wolters Kluwer Health, 2020)The capillaries of the brain are particularly special, as they are not simply conduits for blood, but are primarily responsible to ensure that the neurons function in a strictly regulated homeostatic interstitium. Brain ... -
High levels of oxidation–reduction potential in frozen-thawed human semen are significantly correlated with poor post-thaw sperm quality
(Wiley-Blackwell, 2020)This study examined the relationship between oxidation–reduction potential (ORP) in frozen-thawed semen and the post-thaw sperm parameters. Levels of ORP were measured in 25 samples from men presenting for routine infertility ... -
Aqueous leaf extract of Sutherlandia frutescens attenuates ROS-induced apoptosis and loss of mitochondrial membrane potential in MPP+-treated SH-SY5Y cells
(University of Benin, 2020)To investigate the neuroprotective activity of the aqueous extract of Sutherlandia frutescens (SF) against 1-methyl-4-phenylpyridinium (MPP+)-induced toxicity in SH-SY5Y neuroblastoma cells. Methods: SH-SY5Y neuroblastoma ... -
Novel additive for sperm cryopreservation media: Holotheria parva coelomic cavity extract protects human spermatozoa against oxidative stress—A pilot study
(Wiley-Blackwell, 2020)Cryopreservation is the most effective method for preserving semen for a long period of time. However, during the freeze–thaw process, production of reactive oxygen species (ROS) leads to a steep reduction in sperm fertility ... -
Scientific landscape of oxidative stress in male reproductive research: A scientometric study
(Elsevier, 2020)Unraveling the role of reactive oxygen species and associated oxidative stress (OS) in male reproduction is one of the key areas of male reproductive research. This article illustrates the scientific landscape of OS in ... -
Quest for the best—a move to anatomical endoscopic enucleation of the prostate
(Wiley-Blackwell, 2020)The history of surgical enucleation for the treatment of lower urinary tract symptoms caused by benign prostatic enlargement dates back more than 100 years (Freyer, 1919). Open prostatec-tomy (OP) is an invasive procedure ... -
An exploratory study of contractile force production in muscle fibers from patients with inflammatory myopathies
(Wiley-Blackwell, 2020)Introduction: The mechanism by which weakness develops in idiopathic inflammatory myopathies (IIMs) is still unclear. In this study we investigated the maximum force of single muscle fibers from patients with IIMs. Methods: ... -
The synergistic and neuroprotective effects of alcohol–antioxidant treatment on blood–brain barrier endothelial cells
(Wiley-Blackwell, 2020)Background: Alcohol (EtOH) is reported to adversely affect one of the most crucial roles of the blood–brain barrier (BBB), the regulation of its permeability, thereby compromising the stability of the homeostatic environment ... -
PICSI vs. MACS for abnormal sperm DNA fragmentation ICSI cases: A prospective randomized trial
(Springer Nature, 2020)Purpose: To know which sperm selection technique, physiological intracytoplasmic sperm injection (PICSI) or magnetic-activated cell sorting (MACS), is better for the selection of sperm with abnormal sperm DNA fragmentation ... -
Seminal oxidation–reduction potential levels are not influenced by the presence of leucocytospermia
(Wiley-Blackwell, 2020)Oxidative stress (OS) is characterised by an excessive amount of reactive oxygen species (ROS) which negatively affect sperm functions. In this study, the influence of leucocytes on seminal oxidation–reduction potential ... -
Is there a link between the pathogenic human Coronavirus envelope protein and immunopathology? A review of the literature
(Frontiers Media S.A., 2020)Since the severe acute respiratory syndrome (SARS) outbreak in 2003, human coronaviruses (hCoVs) have been identified as causative agents of severe acute respiratory tract infections. Two more hCoV outbreaks have since ... -
The effect of Nigella sativa oil and metformin on male seminal parameters and testosterone in Wistar rats exposed to an obesogenic diet
(Elsevier, 2020)Obesity is a significant global health and socio-economic challenge, and considered an important risk factor for poor health outcomes including male reproductive dysfunction and infertility. As excess adiposity causes ... -
An insight into the mechanism of holamine- and funtumine-induced cell death in cancer cells
(MDPI, 2020)Holamine and funtumine, steroidal alkaloids with strong and diverse pharmacological activities are commonly found in the Apocynaceae family of Holarrhena. The selective anti-proliferative and cell cycle arrest effects of ... -
Silver nanoparticles stimulates spermatogenesis impairments and hematological alterations in testis and epididymis of Male rats
(MDPI, 2020)The potential pharmaceutical application of nanoparticles has led to the toxicity within the male reproductive system. In the present study, the effects of silver nanoparticles (Ag-NPs) on hematological parameters, free ... -
Alkaloids: Therapeutic Potential against Human Coronaviruses
(MPDI, 2020)Alkaloids are a class of natural products known to have wide pharmacological activity and have great potential for the development of new drugs to treat a wide array of pathologies. Some alkaloids have antiviral activity ... -
Causes and consequences of sperm mitochondrial dysfunction
(Wiley-Blackwell, 2020)Mitochondria have multiple functions, including synthesis of adenine triphosphate, production of reactive oxygen species, calcium signalling, thermogenesis and apoptosis. Mitochondria have a significant contribution in ... -
Ethnopharmacology, therapeutic properties and nutritional potentials of Carpobrotus edulis: A comprehensive review
(MPDI, 2020)Carpobrotus edulis, formerly known as Mesembryanthemum edule L, belongs to the Aizoaceae family of plants. It is a facultative halophytic invasive medicinal and edible succulent plant that is native to South Africa and ... -
Tyrosinase and melanogenesis inhibition by indigenous African plants: A review
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)The indiscriminate use of non-regulated skin lighteners among African populations has raised health concerns due to the negative effects associated with skin lightener toxicity. For this reason, there is a growing interest ... -
Reactive oxygen species in male reproduction: A boon or a bane?
(Wiley, 2020)Reactive oxygen species (ROS) are free radicals derived from oxygen during normal cellular metabolism. ROS play a crucial role in the physiological processes and signalling pathways associated with male fertility. At ...