Browsing Medical Bioscience by Issue Date
Now showing items 161-180 of 277
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Total antioxidant capacity—Relevance, methods and clinical implications
(Blackwell Publishing Ltd, 2020)Oxidative stress is pre‐empted by an adequate level of antioxidants, which scavenge oxidants when they are produced in excess by different sources, including leukocytes and immature spermatozoa. Enzymatic antioxidants, ... -
Ritalinic acid stimulates human sperm motility and maintains vitality in vitro
(Korean Society for Sexual Medicine and Andrology, 2020)To evaluate the in vitro impact of ritalinic acid (RA), a major metabolite of methylphenidate (drug to treat attention-deficit hyperactivity disorder), on sperm motility, vitality and oxidative stress. Materials and Methods: ... -
The beneficial role of anchomanes difformis in stz-induced reproductive dysfunction in male wistar rats
(Dove Medical Press, 2020)Progression of diabetes mellitus has increasingly led to several diabetic complications. Diabetes is one of the major factors implicated in male reproductive system damage. Recent approaches such as the use of medicinal ... -
Green tea consumption increases sperm concentration and viability in male rats and is safe for reproductive, liver and kidney health
(Springer Nature, 2020)Green tea is a popularly consumed beverage worldwide and contains polyphenols, whose antioxidant activities could improve sperm parameters and fertility thereof. We investigated the effect of green tea on the male rat ... -
Immunological changes during space travel: A ground-based evaluation of the impact of Neutron Dose Rate on Plasma Cytokine levels in human whole blood cultures
(Frontiers Media S.A., 2020)A better understanding of the combined impact of different space stressors on human health is urgently warranted, considering the upcoming long-duration missions beyond lower Earth orbit. Therefore, a growing number of ... -
Sleep deprivation and neurological disorders
(Hindawi, 2020)Sleep plays an important role in maintaining neuronal circuitry, signalling and helps maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian physiology and exerts a negative impact on brain ... -
Differential sensitivity of two endothelial cell lines to hydrogen peroxide toxicity: Relevance for in vitro studies of the blood–brain barrier
(MPDI, 2020)Oxidative stress (OS) has been linked to blood–brain barrier (BBB) dysfunction which in turn has been implicated in the initiation and propagation of some neurological diseases. In this study, we profiled, for the first ... -
Quantitative sperm characteristics of Tankwa goats with special reference to hyperactivated motility
(South African Society for Animal Science, 2020)Computer-assisted semen analysis (CASA) is an automated and objective method of evaluating structural (e.g. morphology) and functional sperm parameters (e.g. motility and hyperactivation). Sperm hyperactivation is essential ... -
A population model for the 2017/18 listeriosis outbreak in South Africa
(PLoS One, 2020-03-12)We introduce a compartmental model of ordinary differential equations for the population dynamics of listeriosis, and we derive a model for analysing a listeriosis outbreak. The model explicitly accommodates neonatal ... -
Biosynthesis, Characterization, and Biological Activities of Procyanidin Capped Silver Nanoparticles
(Multidisciplinary Digital Publishing Institute, 2020-09-19)In this study, procyanidin dimers and Leucosidea sericea total extract (LSTE) were employed in the synthesis of silver nanoparticles (AgNPs) and characterized by ultraviolet-visible (UV-Visible) spectroscopy, high-resolution ... -
Enzymatic detoxification of the fumonisin mycotoxins during dry milling of maize
(Elsevier, 2021)Fumonisin esterase FumD (EC 3.1.1.87), FUMzyme® (BIOMIN, Austria), effectively detoxifies fumonisin B mycotoxins (FB) by hydrolysis and removal of the tricarballylic acid groups. The current study evaluated FumD detoxification ... -
Human coronaviruses: counteracting the damage by storm
(MDPI Viruses, 2021)Over the past 18 years, three highly pathogenic human (h) coronaviruses (CoVs) have caused severe outbreaks, the most recent causative agent, SARS-CoV-2, being the first to cause a pandemic. Although much progress has been ... -
The validity and reliability of computer-aided semen analyzers in performing semen analysis: a systematic review
(AME Publishing, 2021)Infertility is defined as the inability to achieve a clinical pregnancy following one year of regular and timed intercourse without contraception (1). It is estimated that infertility affects approximately 15% of ... -
The role of infections and leukocytes in male infertility
(Blackwell Publishing Ltd, 2021)Declining birth rates are one of the problems facing society today. Male counterparts are responsible for about half of the infertility cases, and genitourinary tract infections may play a contributing role in approximately ... -
Environmental contaminants and male infertility: Effects and mechanisms
(Blackwell Publishing Ltd, 2021)The escalating prevalence of male infertility and decreasing trend in sperm quality have been correlated with rapid industrialisation and the associated discharge of an excess of synthetic substances into the environment. ... -
Diagnostic value of advanced semen analysis in evaluation of male infertility
(Blackwell Publishing Ltd, 2021)Conventional semen analysis is the standard of care to initially evaluate the fertility status of a male patient. However, it has some limitations and among these are failure to correctly identify the aetiology underlying ... -
An update on the techniques used to measure oxidative stress in seminal plasma
(Blackwell Publishing Ltd, 2021)Reactive oxygen species (ROS) are produced in significant amounts by spermatozoa and leucocytes. They are necessary to carry out various physiological functions such as sperm capacitation, hyperactivation, acrosome reaction, ... -
Protein profiling in unlocking the basis of varicocele-associated infertility
(Blackwell Publishing Ltd, 2021)Varicocele is one of the major causes of male infertility and has a negative impact on spermatogenesis. The conventional semen analysis does not reveal the underlying subcellular mechanisms associated with defects in ... -
Regulation of AKT/AMPK signaling, autophagy and mitigation of apoptosis in Rutin-pretreated SH-SY5Y cells exposed to MPP+
(Springer Nature, 2021)Accumulating evidence suggest that apoptosis, autophagy and dysregulation of signaling pathways are common mechanisms involved in Parkinson’s disease (PD) pathogenesis, and thus development of therapeutic agents targeting ... -
The effect of Nigella sativa oil and metformin on male seminal parameters and testosterone in Wistar rats exposed to an obesogenic diet
(Elsevier, 2021)Obesity is a significant global health and socio-economic challenge, and considered an important risk factor for poor health outcomes including male reproductive dysfunction and infertility. As excess adiposity causes ...