Browsing Medical Bioscience by Issue Date
Now showing items 201-220 of 277
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High-resolution insights into the in vitro developing blood-brain barrier: Novel morphological features of endothelial nanotube function
(Frontiers Media, 2021)High-resolution electron microscopy (HREM) imaging of the in vitro blood-brain barrier (BBB), is a promising modality for investigating the dynamic morphological interplay underpinning BBB development. The successful ... -
A scientometric analysis of research publications on male infertility and assisted reproductive technology
(Blackwell Publishing Ltd, 2021)Assisted reproductive technologies (ART) are considered as one of the primary management options to address severe male factor infertility. The purpose of this study was to identify the research trends in the field of male ... -
The effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcome
(Wiley, 2021)Our study objective was to assess the effect of various sperm DNA fragmentation levels on clinical intracytoplasmic sperm injection outcome. This retrospective study included 392 patients who underwent ICSI and performed ... -
Male infertility, oxidative stress and antioxidants
(IntechOpen, 2021)Within the male reproductive system, oxidative stress (OS) has been identified as prevailing etiology of male infertility. The effects of reactive oxygen species (ROS) on male fertility depend on the dimensions, “modus ... -
Relevance of leukocytospermia and semen culture and its true place in diagnosing and treating male infertility
(Korean Society for Sexual Medicine and Andrology, 2021)The current WHO 2010 manual for human semen analysis defines leukocytospermia as the presence of peroxidase-positive leukocytes at a concentration >1×106 /mL of semen. Granular leukocytes when activated are capable of ... -
Sperm morphology assessment in the era of intracytoplasmic sperm injection: Reliable results require focus on standardization, quality control, and training
(Korean Society for Sexual Medicine and Andrology, 2021)Semen analysis is the first, and frequently, the only step in the evaluation of male fertility. Although the laboratory procedures are conducted according to the World Health Organization (WHO) guidelines, semen analysis ... -
Etiologies of sperm DNA damage and its impact on male infertility
(Blackwell Publishing Ltd, 2021)Male factor is responsible for up to 50% of infertility cases in the world. Semen analysis is considered the cornerstone of laboratory evaluation of male infertility, but it has its own drawbacks and fails to predict the ... -
Semiquantitative promoter methylation of MLH1 and MSH2 genes and their impact on sperm DNA fragmentation and chromatin condensation in infertile men
(Blackwell Publishing Ltd, 2021)To investigate the semiquantitative methylation alterations of MLH1 and MSH2 and the possible association among methylation of MLH1 and MSH2, sperm DNA fragmentation and sperm chromatin condensation in idiopathic ... -
Response to letter to the Editor: The therapeutic strategy of drug re-positioning to induce autophagic cell death in brain malignancy
(Springer Nature, 2021)We thank Dr Yoshida for his valuable comments and interest in our study which describes the anti-cancer activity of DS00329, a novel derivative of the anti-psychotic drug phenothiazine, in glioblastoma multiforme (GBM) ... -
Corrigendum: Immunological changes during space travel: A ground-based evaluation of the impact of neutron dose rate on plasma cytokine levels in human whole blood cultures
(Frontiers Media, 2021)A better understanding of the combined impact of different space stressors on human health is urgently warranted, considering the upcoming long-duration missions beyond lower Earth orbit. Therefore, a growing number of ... -
Leptin deficiency, caused by malnutrition, makes you susceptible to sars-cov-2 infection but could offer protection from severe Covid-19
(American Society for Microbiology, 2021)In much of the developing world, severe malnutrition is the most prevalent cause of immunodeficiency and affects up to 50% of the population in some impoverished communities. As yet, we do not know how severe acute ... -
Editorial commentary on draft of world health organization sixth edition laboratory manual for the examination and processing of human semen
(Korean Society for Sexual Medicine and Andrology, 2021)Semen examination is the cornerstone of the evaluation of male fertility potential. Despite its apparent simplicity, it is a complex series of assessments with highly variable results that are subject to interpretation. ... -
The new 6th edition of the WHO laboratory manual for the examination and processing of human semen: Is it a step toward better standard operating procedure?
(Shanghai Institute Materia Medica, 2021)Semen analysis (SA) remains the cornerstone of male infertility evaluation and should ideally be performed by an accredited andrology laboratory or in vitro fertilization (IVF) clinics based on the standards defined ... -
The Impact of Health Disparities on COVID-19 Outcomes: Early Findings from a High-Income Country and Two Middle-Income Countries
(Springer, 2021)The SARS-CoV-2 infection, which causes the coronavirus disease (COVID-19), has affected lives, with very adverse outcomes in specific populations in the United States of America (USA), a high-income country, and two ... -
Utility of Antioxidants in the Treatment of Male Infertility: Clinical Guidelines Based on a Systematic Review and Analysis of Evidence
(The world journal of men's health, 2021)It is widely accepted that oxidative stress plays an important role in the pathophysiology of male infertility and that antioxidants could have a significant role in the treatment of male infertility. The main objectives ... -
Relevance of leukocytospermia and semen culture and its true place in diagnosing and treating male infertility
(Korean Society for Sexual Medicine and Andrology, 2021)The current WHO 2010 manual for human semen analysis defines leukocytospermia as the presence of peroxidase-positive leukocytes at a concentration >1×106 /mL of semen. Granular leukocytes when activated are capable of ... -
Differential effects of normoxic versus hypoxic derived breast cancer paracrine factors on brain endothelial cells
(MPDI, 2021)The blood-brain barrier (BBB) is a central nervous system protective barrier formed primarily of endothelial cells that regulate the entry of substances and cells from entering the brain. However, the BBB integrity is ... -
The sixth edition of the WHO manual for human semen analysis: A critical review and SWOT analysis
(MDPI, 2021)Semen analysis is the cornerstone of male fertility evaluation with WHO guidelines providing the basis for procedural standardization and reference values worldwide. The first WHO manual was published in 1980, and five ... -
Endocrine contribution to the sexual dysfunction in patients with advanced chronic kidney disease and the role of hyperprolactinemia
(John Wiley and Sons Inc, 2021)In this study, we investigated the prevalence of sexual dysfunction among males with advanced chronic kidney disease and the effect of treating hyperprolactinemia among these patients. In this prospective study, patients ... -
Functional landscape of SARS-CoV-2 cellular restriction
(Cell Press, 2021)A deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus disease 2019 (COVID-19). To identify the molecular ...