Browsing Medical Bioscience by Issue Date
Now showing items 221-240 of 277
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Data Management Plans in the genomics research revolution of Africa: Challenges and Recommendations
(Elsevier, 2021)Drafting and writing a data management plan (DMP) is increasingly seen as a key part of the academic research process. A DMP is a document that describes how a researcher will collect, document, describe, share, and preserve ... -
Association among sperm chromatin condensation, sperm DNA fragmentation and 8-OHdG in seminal plasma and semen parameters in infertile men with oligoasthenoteratozoospermia
(Wiley, 2021)The present study aimed to investigate the clinical role of standard sperm diagnosis parameters (sperm concentration, motility, morphology) as well as aniline blue staining of histones, 8-OHdG, TUNEL assay were performed ... -
Polymorphisms of androgens-related genes and idiopathic male infertility in Turkish men
(Wiley, 2021)Androgens, testosterone and dihydrotestosterone (DHT) are endocrine regulators of spermatogenesis and act via androgen receptor (AR). The aim of this study was to investigate the association(s) of AR (CAG repeat length), ... -
Oxidative stress: A comprehensive review of biochemical, molecular, and genetic aspects in the pathogenesis and management of varicocele
(Korean Society for Sexual Medicine and Andrology, 2021)Sperm vitality testing is a basic semen examination that has been described in the World Health Organization (WHO) Laboratory Manual for the Examination and Processing of Human Semen from its primary edition, 40 years ago. ... -
Male age and progressive sperm motility are critical factors affecting embryological and clinical outcomes in oocyte donor ICSI cycles
(Reproductive Sciences, 2021)This retrospective cohort study aimed to explore whether paternal age and semen quality parameters affect the embryological and clinical outcomes of ICSI with oocyte donation. A total of 339 oocyte donation (OD)-ICSI cycles ... -
Radiosensitization effect of gold nanoparticles in proton therapy
(Frontiers Media, 2021)The number of proton therapy facilities and the clinical usage of high energy proton beams for cancer treatment has substantially increased over the last decade. This is mainly due to the superior dose distribution of ... -
Morphological and physiological responses of Calobota sericea plants subjected to water limitation and subsequent rewatering
(Taylor and Francis Group, 2021)Calobota sericea is a native legume of South Africa, confined to the water-limited rangelands, and it has recently been prioritised for additional characterisation regarding its pasture potential. In this study, we examined ... -
The effects of in utero exposure to teratogens on organ size: A prospective paediatric study
(Cambridge University Press, 2021)In low-income countries, prospective data on combined effects of in utero teratogen exposure are lacking and necessitates new research. The aim of the present study was to explore the effect of in utero teratogen exposure ... -
Maternal and Neonatal Group B Streptococcus colonisation in a cohort of Libyan women
(2021-01-18)Background: Group B streptococcus (GBS) may be vertically transmitted from mother to infant during labour and cause life threatening neonatal sepsis. The objective of this study was to determine the risk and prevalence ... -
Real-time assessment of Candida biofilm formation
(Elsevier, 2021-09)Background: Candida infections are responsible for increased morbidity and mortality in immunocompromised patients, particularly when the Candida biofilm is composed of drug-resistant species. Although the biofilm formation ... -
HPLC-MS identification and expression of Candida drug-resistance proteins from African HIV-infected patients
(AIMS Press, 2021-09-10)The objective of this study was to elucidate the proteomic mechanisms of drug resistance in HIV-infected African patients. Cell membrane fractions from forty oral Candida isolates isolated from African HIV-positive patients ... -
In Silico Sperm Proteome Analysis to Investigate DNA Repair Mechanisms in Varicocele Patients
(Frontiers Media S.A., 2021-12-17)Varicocele, a condition associated with increased oxidative stress, negatively affects sperm DNA integrity and reduces pregnancy rates. However, the molecular mechanisms related to DNA integrity, damage, and repair in ... -
Role of cytocentrifugation combined with nuclear fast picroindigocarmine staining in detecting cryptozoospermia in men diagnosed with azoospermia
(Seoul: Korean Society for Sexual Medicine and Andrology, 2022)Azoospermia is defined as the absence of spermatozoa in the pellet of a centrifuged semen sample. In fact, when a basic semen analysis fails to detect sperm in the ejaculate, there is still the possibility of detecting ... -
Psychosocial reintegration following traumatic spinal cord injury in South Africa: The influence of employment, injury characteristics and living situation
(The Journal of Spinal Cord Medicine,, 2022)1Department of Health and Rehabilitation Sciences, Division of Physiotherapy, Stellenbosch University, Cape Town, South Africa, 2Department of Physiotherapy, University of the Western Cape, Cape Town, South Africa Objectives: ... -
Origin, Migration, and Reproduction of Indigenous Domestic Animals with Special Reference to Their Sperm Quality
(MDPI, 2022): Indigenous domestic animals such as cattle, sheep, goats, pigs, and chickens have a natural resistance to endo- and ecto-parasites and are tolerant in terms of harsh environmental conditions. These species orginated ... -
In vitro effects of aqueous extract of unfermented rooibos on human spermatozoa
(Wiley, 2022)The inability to conceive is a baleful experience for thousands of couples worldwide. Among different well-known reproductive techniques, medicinal plants have been utilized to treat male infertility. Medicinal plants, ... -
The paracrine effect of hypoxic and normoxic cancer secretion on the proliferation of brain endothelial cells (bend.3)
(MDPI, 2022): Background: This study aimed to investigate the disruption of cell cycle phases of bEnd.3 cells exposed to cancer paracrine secretion. Cancer cells have been reported to use the secretion of paracrine factors to ... -
Comparative study of the antioxidant constituents, activities and the gc-ms quantification and identification of fatty acids of four selected helichrysum species
(MDPI, 2022)Helichrysum Mill. (Asteraceae) is a plant genus comprising distinctively of aromatic plants of about 500–600 species. Since most of these plants have not been previously studied, extensive profiling helps to validate ... -
Characterization and Toxicity of Hypoxoside Capped Silver Nanoparticles
(MDPI, 2022)The reducing potential of plant extracts in the green synthesis of nanoparticles has been associated with their phytochemicals. Although pharmacologically inactive, a norlignan diglucoside “hypoxoside” (HP) occurs in large ... -
Effect of maternal cigarette smoking and alcohol consumption during pregnancy on birth weight and cardiometabolic risk factors in infants, children and adolescents: A systematic review protocol
(BMC, 2022)Tobacco smoking and alcohol consumption during pregnancy are particularly prevalent in low socioeconomic status populations, with an adverse association with birth outcomes and cardiometabolic risk factors. However, ...