Browsing Medical Bioscience by Author "Henkel, Ralf"
Now showing items 41-60 of 63
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Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort
Leisegang, Kristian; Menkveld, Roelof; Bouic, Patrick J.D.; Henkel, Ralf (BioMed Central, 2014)Obesity appears to be associated with male reproductive dysfunction and infertility, although this has been inconsistent and inconclusive. Insulin and leptin are known mediators and modulators of the hypothalamus-pituitary-testes ... -
Oxidative stress and assisted reproduction: A comprehensive review of its pathophysiological role and strategies for optimizing embryo culture environment
Agarwal, Ashok; Rosas, Israel Maldonado; Henkel, Ralf (MDPI, 2022)Oxidative stress (OS) due to an imbalance between reactive oxygen species (ROS) and antioxidants has been established as an important factor that can negatively affect the outcomes of assisted reproductive techniques ... -
Oxidative stress: A comprehensive review of biochemical, molecular, and genetic aspects in the pathogenesis and management of varicocele
Henkel, Ralf; Agarwal, Ashok; Sharma, Rakesh K; Gupta, Sajal (Korean Society for Sexual Medicine and Andrology, 2021)Sperm vitality testing is a basic semen examination that has been described in the World Health Organization (WHO) Laboratory Manual for the Examination and Processing of Human Semen from its primary edition, 40 years ago. ... -
PICSI vs. MACS for abnormal sperm DNA fragmentation ICSI cases: A prospective randomized trial
Henkel, Ralf; Hasanen, Eman; Elqusi, Khaled (Springer Nature, 2020)Purpose: To know which sperm selection technique, physiological intracytoplasmic sperm injection (PICSI) or magnetic-activated cell sorting (MACS), is better for the selection of sperm with abnormal sperm DNA fragmentation ... -
Quest for the best—a move to anatomical endoscopic enucleation of the prostate
Henkel, Ralf; Cho, Chaklam; Teoh, Jeremy Yuen Chun (Wiley-Blackwell, 2020)The history of surgical enucleation for the treatment of lower urinary tract symptoms caused by benign prostatic enlargement dates back more than 100 years (Freyer, 1919). Open prostatec-tomy (OP) is an invasive procedure ... -
Radiations and male fertility
Kesari, Kavindra Kumar; Agarwal, Ashok; Henkel, Ralf (Springer Nature, 2018)During recent years, an increasing percentage of male infertility has to be attributed to an array of environmental, health and lifestyle factors. Male infertility is likely to be affected by the intense exposure to heat ... -
Reactive oxygen species and male reproductive hormones
Darbandi, Mahsa; Darbandi, Sara; Agarwal, Ashok; Sengupta, Pallav; Durairajanayagam, Damayanthi; Henkel, Ralf; Sadeghi, Mohammad Reza (BMC, 2018)Reports of the increasing incidence of male infertility paired with decreasing semen quality have triggered studies on the effects of lifestyle and environmental factors on the male reproductive potential. There are ... -
Reactive oxygen species and male reproductive hormones
Darbandi, Mahsa; Darbandi, Sara; Agarwal, Ashok; Sengupta, Pallav; Durairajanayagam, Damayanthi; Henkel, Ralf; Sadeghi, Mohammad Reza (BMC, 2018)Reports of the increasing incidence of male infertility paired with decreasing semen quality have triggered studies on the effects of lifestyle and environmental factors on the male reproductive potential. There are ... -
Reactive oxygen species in male reproduction: A boon or a bane?
Finelli, Renata; Henkel, Ralf; Baskaran, Saradha (Wiley, 2020)Reactive oxygen species (ROS) are free radicals derived from oxygen during normal cellular metabolism. ROS play a crucial role in the physiological processes and signalling pathways associated with male fertility. At ... -
The relationship between seminal leukocytes, oxidative status in the ejaculate, and apoptotic markers in human spermatozoa
Mupfiga, Cleyson; Fisher, David; Kruger, Thinus; Henkel, Ralf (Taylor & Francis, 2013)The aim of this study was to investigate the relationship between seminal leukocytes, reactive oxygen species (ROS) production in the ejaculate, and markers of apoptosis in human spermatozoa. Semen samples were collected ... -
Relevance of leukocytospermia and semen culture and its true place in diagnosing and treating male infertility
Sharma, Rakesh; Gupta, Sajal; Henkel, Ralf (Korean Society for Sexual Medicine and Andrology, 2021)The current WHO 2010 manual for human semen analysis defines leukocytospermia as the presence of peroxidase-positive leukocytes at a concentration >1×106 /mL of semen. Granular leukocytes when activated are capable of ... -
Relevance of leukocytospermia and semen culture and its true place in diagnosing and treating male infertility
Sharma, Rakesh; Gupta, Sajal; Henkel, Ralf (Korean Society for Sexual Medicine and Andrology, 2021)The current WHO 2010 manual for human semen analysis defines leukocytospermia as the presence of peroxidase-positive leukocytes at a concentration >1×106 /mL of semen. Granular leukocytes when activated are capable of ... -
Reply to Pallotti et al. comment on “Boitrelle et al. The sixth edition of the who manual for human semen analysis: A critical review and swot analysis. Life 2021, 11, 1368"
Boitrelle, Florence; Shah, Rupin; Henkel, Ralf (MDPI, 2022)We would like to thank F. Pallotti and his colleagues for their positive comments [1] on our SWOT analysis of the strengths, weaknesses, threats and opportunities of the sixth edition of the WHO manual on semen analysis ... -
Ritalinic acid stimulates human sperm motility and maintains vitality in vitro
Henkel, Ralf; Harlev, A.; Samanta, Luna (Korean Society for Sexual Medicine and Andrology, 2020)To evaluate the in vitro impact of ritalinic acid (RA), a major metabolite of methylphenidate (drug to treat attention-deficit hyperactivity disorder), on sperm motility, vitality and oxidative stress. Materials and Methods: ... -
Role of cytocentrifugation combined with nuclear fast picroindigocarmine staining in detecting cryptozoospermia in men diagnosed with azoospermia
Sharma, Rakesh Kumar; Henkel, Ralf (Seoul: Korean Society for Sexual Medicine and Andrology, 2022)Azoospermia is defined as the absence of spermatozoa in the pellet of a centrifuged semen sample. In fact, when a basic semen analysis fails to detect sperm in the ejaculate, there is still the possibility of detecting ... -
Scientific landscape of oxidative stress in male reproductive research: A scientometric study
Henkel, Ralf; Agarwal, Ashok; Baskaran, Saradha (Elsevier, 2020)Unraveling the role of reactive oxygen species and associated oxidative stress (OS) in male reproduction is one of the key areas of male reproductive research. This article illustrates the scientific landscape of OS in ... -
Seminal oxidation–reduction potential levels are not influenced by the presence of leucocytospermia
Henkel, Ralf; Arafa, Mohamed Mostafa; Agarwal, Ashok (Wiley-Blackwell, 2020)Oxidative stress (OS) is characterised by an excessive amount of reactive oxygen species (ROS) which negatively affect sperm functions. In this study, the influence of leucocytes on seminal oxidation–reduction potential ... -
Semiquantitative promoter methylation of MLH1 and MSH2 genes and their impact on sperm DNA fragmentation and chromatin condensation in infertile men
Henkel, Ralf; Hekim, N; Gunes, S (Blackwell Publishing Ltd, 2021)To investigate the semiquantitative methylation alterations of MLH1 and MSH2 and the possible association among methylation of MLH1 and MSH2, sperm DNA fragmentation and sperm chromatin condensation in idiopathic ... -
A simple point of care test can indicate the need for periodontal therapy to reduce the risk for adverse pregnancy outcomes in mothers attending antenatal clinics
Turton, Mervyn Sydney; Africa, Charlene W.J.; Henkel, Ralf; Africa, Charlene W.J. (Taylor & Francis Group, 2017)INTRODUCTION: Although the association between periodontal disease (PD) and adverse pregnancy outcomes has gained recognition amongst antenatal healthcare workers, not much has changed in practice to address it. This ... -
Smoking‐induced genetic and epigenetic alterations in infertile men
Gunes, Sezgin; Mahmutoglu, Asli Metin; Arslan, Mehmet Alper; Henkel, Ralf (Wiley, 2018)Male fertility rates have shown a progressive decrease in both developing and industrialised countries in the past 50 years. Clinical and epidemiological studies have demonstrated controversial results about the harmful ...