Browsing Medical Bioscience by Author "Rado, Mariam"
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Differential effects of normoxic versus hypoxic derived breast cancer paracrine factors on brain endothelial cells
Rado, Mariam; Flepisi, Brian; Fisher, David (MPDI, 2021)The blood-brain barrier (BBB) is a central nervous system protective barrier formed primarily of endothelial cells that regulate the entry of substances and cells from entering the brain. However, the BBB integrity is ... -
Differential sensitivity of two endothelial cell lines to hydrogen peroxide toxicity: Relevance for in vitro studies of the blood–brain barrier
Alamu, Olufemi; Rado, Mariam; Ekpo, Okobi (MPDI, 2020)Oxidative stress (OS) has been linked to blood–brain barrier (BBB) dysfunction which in turn has been implicated in the initiation and propagation of some neurological diseases. In this study, we profiled, for the first ... -
The paracrine effect of hypoxic and normoxic cancer secretion on the proliferation of brain endothelial cells (bend.3)
Rado, Mariam; Fisher, David (MDPI, 2022): Background: This study aimed to investigate the disruption of cell cycle phases of bEnd.3 cells exposed to cancer paracrine secretion. Cancer cells have been reported to use the secretion of paracrine factors to ...