Medical Bioscience: Recent submissions
Now showing items 1-20 of 277
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Evaluation of synergistic anticandidal activity of galenia africana extract and fluconazole against candida albicans and candida glabrata
(Elsevier, 2022-03)Candida infections have increased in recent years and are causing a serious public health concern. In addition, Candida species are becoming resistant to numerous antifungal drugs. It is for this reason that alternative ... -
Overview of the effects of moringa oleifera leaf extract on oxidative stress and male infertility: a review
(MDPI, 2023)According to a recent report by the WHO, 50–80 million people suffer with infertility. Amongst these populations, male counterparts account for 20–50% of infertility cases. The aetiology of infertility in men includes many ... -
Controversy and consensus on indications for sperm dna fragmentation testing in male infertility: a global survey, current guidelines, and expert recommendations
(Korean Society for Sexual Medicine and Andrology, 2023)Purpose: Sperm DNA fragmentation (SDF) testing was recently added to the sixth edition of the World Health Organization laboratory manual for the examination and processing of human semen. Many conditions and risk factors ... -
The pathophysiology of rhabdomyolysis in ungulates and rats: towards the development of a rodent model of capture myopathy
(Springer, 2023)Capture myopathy (CM), which is associated with the capture and translocation of wildlife, is a life-threatening condition that causes noteworthy morbidity and mortality in captured animals. Such wildlife deaths have a ... -
Microplastic sources, formation, toxicity and remediation: A review
(Springer, 2023)Microplastic pollution is becoming a major issue for human health due to the recent discovery of microplastics in most ecosystems. Here, we review the sources, formation, occurrence, toxicity and remediation methods of ... -
Effects of temperature and storage time on the motility, viability, DNA integrity and apoptosis of processed human spermatozoa
(Wiley, 2019)The aim of this study was to evaluate motility, viability, DNA integrity and apoptosis of spermatozoa when washed semen samples were kept for up to 12 days at 4–6°C and 25°C. In this experimental study, 26 normozoospermic ... -
Critical evaluation of two models of flow cytometers for the assessment of sperm DNA fragmentation: an appeal for performance verification
(Medknow Publications, 2019)Lack of standardized, reproducible protocols and reference values is among the challenges faced when using new or upgraded versions of instruments in reproductive laboratories and flow cytometry. Terminal deoxynucleotidyl ... -
Autoimmune progesterone dermatitis: Case report with history of urticaria, petechiae and palpable pinpoint purpura triggered by medical abortion
(South African Medical Association, 2016)Autoimmune progesterone dermatitis (APD) is a rare autoimmune response to raised endogenous progesterone levels that occur during the luteal phase of the menstrual cycle. Cutaneous, mucosal lesions and other systemic ... -
Contaminants of emerging concern (cecs) and male reproductive health: Challenging the future with a double-edged sword
(MDPI, 2023)Approximately 9% of couples are infertile, with half of these cases relating to male factors. While many cases of male infertility are associated with genetic and lifestyle factors, approximately 30% of cases are still ... -
Trends in semen parameters of infertile men in South Africa and Nigeria
(2023)There are conflicting reports on trends of semen parameters from different parts of the globe. However, in recent times there is dearth of information on the trend in Sub-Saharan countries. Therefore, in this study we ... -
Fiber type and metabolic characteristics of skeletal muscle in 16 breeds of domestic dogs
(Wiley, 2023)The domestic dog (Canis lupus familiaris) species comprises hundreds of breeds, each differing in physical characteristics, behavior, strength, and running capability. Very little is known about the skeletal muscle ... -
A plant-produced SARS-CoV-2 spike protein elicits heterologous immunity in hamsters
(Frontiers Media, 2023)Molecular farming of vaccines has been heralded as a cheap, safe and scalable production platform. In reality, however, differences in the plant biosynthetic machinery, compared to mammalian cells, can complicate the ... -
Unveiling the Inhibitory Potentials of Peptidomimetic Azanitriles and Pyridyl Esters towards SARS-CoV-2Main Protease: A MolecularModelling Investigation
(MDPI, 2023)The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for COVID-19, which was declared a global pandemic in March 2020 by the World Health Organization (WHO). Since SARS-CoV-2 main protease plays ... -
Use of a rat ex-vivo testis culture method to assess toxicity of select known male reproductive toxicants
(Elsevier, 2016)Due to the complex physiology of the testes, in vitro models have been largely unsuccessful at modeling testicular toxicity in vivo. We conducted a pilot study to evaluate the utility of the Durand ex vivo rat seminiferous ... -
Muscle fiber type and metabolic profiles of four muscles from the African black ostrich
(Meat Science, 2023)Muscle fiber type, fiber cross-sectional area (CSA), enzyme activities (citrate synthase (CS), 3-hydroxyacetyl Co A dehydrogenase (3HAD), lactate dehydrogenase (LDH) and phosphofructokinase (PFK)) and glycogen content were ... -
Potential for increasing folate contents of traditional African fermented sorghum gruel (Motoho) using presumptive probiotic lactic acid bacteria
(Elsevier, 2023)Folate deficiency is commonly observed in most developing countries. Lactic acid bacteria (LAB) fermentation of cereal-based foods could be an alternative to improving folate intake. This study evaluated the possibility ... -
The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson’s disease data
(Nature Research, 2023)Open science and collaboration are necessary to facilitate the advancement of Parkinson’s disease (PD) research. Hackathons are collaborative events that bring together people with different skill sets and backgrounds to ... -
Call for special issue papers: Global public health — contributions of traditional, complementary, and integrative medicine in primary care
(Mary Ann Liebert, 2022)The 2018 Declaration of Astana* issued by the World Health Organization (WHO) and the United Nations Children’s Fund (UNICEF) represents a landmark step for all of primary health care, public health, and traditional co ... -
Face-to-face versus online-based lectures: A COVID-19 induced study on assessments
(Frontiers in Education, 2022)The students were found to be resilient in adapting to things and learning, online presentations, and computer-based assessments. No gender-based difference or advantage to adjusting to newly introduced blended learning ... -
Green nanotechnology as an innovative drug delivery approach for typha capensis and naringenin—new class of phytochemical embedded biocompatible gold nanoparticles in prostate cancer therap
(Journal of Drug Delivery Science and Technology, 2022)Naringenin, a flavone with a growing body of evidence as an anti-cancer agent, is found in Typha capensis, an indigenous South African plant commonly used in traditional medicine. However, despite favourable in vitro ...