Browsing Research Articles (Medical Bioscience) by Title
Now showing items 136-155 of 256
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An insight into the mechanism of holamine- and funtumine-induced cell death in cancer cells
(MDPI, 2020)Holamine and funtumine, steroidal alkaloids with strong and diverse pharmacological activities are commonly found in the Apocynaceae family of Holarrhena. The selective anti-proliferative and cell cycle arrest effects of ... -
Interpretation of semen analysis using WHO 1999 and WHO 2010 reference values: abnormal becoming normal
(Wiley, 2017)Reference values of WHO 1999 manual were used for the interpretation of semen analysis until 2010 when new reference values were introduced which have lower cut-off compared to WHO 1999. Therefore, several men who previously ... -
Interventions to reduce pesticide exposure from the agricultural sector in Africa: A workshop report
(MDPI, 2022)Despite the fact that several cases of unsafe pesticide use among farmers in different parts of Africa have been documented, there is limited evidence regarding which specific interventions are effective in reducing ... -
The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson’s disease data
(Nature Research, 2023)Open science and collaboration are necessary to facilitate the advancement of Parkinson’s disease (PD) research. Hackathons are collaborative events that bring together people with different skill sets and backgrounds to ... -
Is human Immunodeficiency Virus (HIV) stage an independent risk factor for altering the periodontal status of HIV-positive patients? A South African study
(BioMed Central, 2013)Background: The immunosuppresion in HIV patients makes them highly susceptible to microbial infections. The aim of the study was to establish whether HIV stage (as depicted by CD4+ T lymphocyte counts) could independently ... -
Is human immunodeficiency virus (HIV) stage an independent risk factor for altering the periodontal status of HIV-positive patients? A South African study
(BMC, 2013)The immunosuppresion in HIV patients makes them highly susceptible to microbial infections. The aim of the study was to establish whether HIV stage (as depicted by CD4+ T lymphocyte counts) could independently be associated ... -
Is there a link between the pathogenic human Coronavirus envelope protein and immunopathology? A review of the literature
(Frontiers Media S.A., 2020)Since the severe acute respiratory syndrome (SARS) outbreak in 2003, human coronaviruses (hCoVs) have been identified as causative agents of severe acute respiratory tract infections. Two more hCoV outbreaks have since ... -
Is there plagiarism in the most influential publications in the field of andrology?
(Wiley, 2019)Plagiarism is a common form of academic misconduct that extensively jeopardises the quality of scientific publication. The purpose of this study is to determine the extent of plagiarism in the most influential andrology ... -
Is there plagiarism in the most influential publications in the field of andrology?
(Wiley Online Library, 2019)Plagiarism is a common form of academic misconduct that extensively jeopardises the quality of scientific publication. The purpose of this study is to determine the extent of plagiarism in the most influential andrology ... -
The Ism between endothelial cilia and endothelial nanotubules is an evolving concept in the genesis of the BBB
(MDPI, 2022)The blood–brain barrier (BBB) is fundamental in maintaining central nervous system (CNS) homeostasis by regulating the chemical environment of the underlying brain parenchyma. Brain endothelial cells (BECs) constitute ... -
K21 compound, a potent antifungal agent: Implications for the treatment of fluconazole-resistant HIV-associated Candida species
(Frontiers, 2019-05-24)Background/objectives: With mucocutaneous candidiasis being highly prevalent in HIV patients, the emergence of fluconazole-resistant Candida species forms a major challenge in treating and eradicating these infections. The ... -
Leptin deficiency, caused by malnutrition, makes you susceptible to sars-cov-2 infection but could offer protection from severe Covid-19
(American Society for Microbiology, 2021)In much of the developing world, severe malnutrition is the most prevalent cause of immunodeficiency and affects up to 50% of the population in some impoverished communities. As yet, we do not know how severe acute ... -
Life-long programming implications of exposure to tobacco smoking and nicotine before and soon after birth: Evidence for altered lung development
(MDPI, 2011)Tobacco smoking during pregnancy remains common, especially in indigenous communities, and likely contributes to respiratory illness in exposed offspring. It is now well established that components of tobacco smoke, notably ... -
Male infertility
(Lancet Publishing Group, 2021)It is estimated that infertility affects 8–12% of couples globally, with a male factor being a primary or contributing cause in approximately 50% of couples. Causes of male subfertility vary highly, but can be related to ... -
Measuring Streptococcus mutans, Streptococcus sanguinis and Candida albicans biofilm formation using a real-time impedance-based system
(Elsevier, 2019-12-20)Candida albicans and streptococci are amongst the most common fungal and bacterial organisms present in the oral cavity, with a growing body of evidence implicating C. albicans in increased caries severity and in ... -
Medicinal properties and in vitro biological activities of selected helichrysum species from South Africa: A review
(MDPI, 2021)The genus Helichrysum Mill comprises hundreds of species that are mostly flowering perennial shrubs. Some of these plants that belong to the Helichrysum species are used in traditional medicine to treat cough, back pain, ... -
MERS-CoV: Understanding the latest human coronavirus threat
(MDPI, 2018)Human coronaviruses cause both upper and lower respiratory tract infections in humans. In 2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe respiratory illness. The 60-year-old man ... -
Metronidazole in the Prophylaxis and treatment of Anaerobic Infection
(Health and Medical Publishing Group, 1978)The influence of prophylactic metronidazole on vaginal carriage rates of anaerobes and the development of postoperative anaerobic infection was studied in 104 women who underwent abdominal hysterectomy. Metronidazole ... -
Microplastic sources, formation, toxicity and remediation: A review
(Springer, 2023)Microplastic pollution is becoming a major issue for human health due to the recent discovery of microplastics in most ecosystems. Here, we review the sources, formation, occurrence, toxicity and remediation methods of ... -
Microstructurally-based constitutive modelling of the skin – Linking intrinsic ageing to microstructural parameters
(Elsevier, 2018)A multiphasic constitutive model of the skin that implicitly accounts for the process of intrinsic (i.e. chronological) ageing via variation of the constitutive parameters is proposed. The structurally-motivated constitutive ...