| dc.contributor.author | Sharma, Jyoti Rajan | |
| dc.contributor.author | Sibuyi, Nicole Remaliah Samantha | |
| dc.contributor.author | Fadaka, Adewale Oluwaseun | |
| dc.date.accessioned | 2023-04-20T09:56:56Z | |
| dc.date.available | 2023-04-20T09:56:56Z | |
| dc.date.issued | 2023 | |
| dc.identifier.citation | Sharma, J. R. et al. (2023). Anticancer and drug-sensitizing activities of gold nanoparticles synthesized from cyclopia genistoides (honeybush) extracts. Applied Sciences, 13(6), 3973. https://doi.org/10.3390/app13063973 | en_US |
| dc.identifier.issn | 2076-3417 | |
| dc.identifier.uri | https://doi.org/10.3390/app13063973 | |
| dc.identifier.uri | http://hdl.handle.net/10566/8842 | |
| dc.description.abstract | Synthesis of gold nanoparticles (AuNPs) using phytochemicals has become tremendously
prominent in biomedical applications because of its enhanced bioactivity and biocompatibility. In
this study, water extracts from the leaves of Cyclopia genistoides (C. genistoides), commonly known
as honeybush (HB), were used to synthesize honeybush gold nanoparticles (HB-AuNPs). The HB
water extracts (HBE) served as both reducing and capping agents in the synthesis of HB-AuNPs.
The HB-AuNPs were characterized by UV–Vis spectrophotometry, dynamic light scattering (DLS),
and transmission electron microscopy (TEM). The cytotoxicity and apoptotic effects of the HBE and
HB-AuNPs, alone and in combination with doxorubicin (Dox), were examined against various human
cell lines. Spherical-shaped HB-AuNPs with a hydrodynamic diameter range of 63 to 121 nm were
produced. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | MDPI | en_US |
| dc.subject | Gold nanoparticles | en_US |
| dc.subject | Biotechnology | en_US |
| dc.subject | Green synthesis | en_US |
| dc.subject | Medicinal plants | en_US |
| dc.subject | Phytotherapy | en_US |
| dc.title | Anticancer and drug-sensitizing activities of gold nanoparticles synthesized from cyclopia genistoides (honeybush) extracts | en_US |
| dc.type | Article | en_US |
