Faculty of Natural Sciences: Recent submissions
Now showing items 1581-1600 of 2642
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History of chronic disease is a novel intrinsic risk factor associated with gradual onset injuries in recreational road cyclists: A cross-sectional study in 21,824 cyclists - SAFER XIV
(Elsevier, 2020)Objectives: Risk factors related to Gradual onset injuries (GOIs) in cyclists need to be identified to enable effective injury prevention strategies. We aim to determine risk factors related to GOIs in cyclists participating ... -
Identification of novel prognostic markers of survival time in high-risk neuroblastoma using gene expression profiles
(Impact Journals, 2020)Neuroblastoma is the most common extracranial solid tumor in childhood. Patients in high-risk group often have poor outcomes with low survival rates despite several treatment options. This study aimed to identify a genetic ... -
MicroRNA-based regulation of Aurora A kinase in breast cancer
(Impact Journals, 2020)The involvement of non-coding RNAs (ncRNAs) in cellular physiology and disease pathogenesis is becoming increasingly relevant in recent years specifically in cancer research. Breast cancer (BC) has become a health concern ... -
A pharmacist-led prospective antibiotic stewardship intervention improves compliance to community-acquired pneumonia guidelines in 39 public and private hospitals across South Africa
(Elsevier, 2020)Introduction: Pharmacists in low-middle-income countries (LMIC) are few and lack antibiotic stewardship (AS) training. The ability was assessed of non-specialised pharmacists to implement stewardship interventions and ... -
Validation of simple dichotomous self-report on prenatal alcohol and other drug use in women attending midwife obstetric units in the Cape Metropole, South Africa
(SAGE, 2020)Background: This paper examines the degree of agreement among simple dichotomous self-report, validated screening results, and biochemical screening results of prenatal alcohol and other drug use among pregnant women. ... -
Exploring the utility of a spontaneous adverse drug reaction reporting system in identifying drug–drug interactions between antiretrovirals, antitubercular drugs, and cotrimoxazole: a case/non-case analysis
(Springer Nature, 2020)Background: Drug–drug interactions (DDIs) cause significant morbidity and mortality, especially in patients with HIV with opportunistic infections such as tuberculosis. However, the literature on quantitative signal detection ... -
Genomic association of single nucleotide polymorphisms with blood pressure response to hydrochlorothiazide among south african adults with hypertension
(MDPI, 2020): This study described single nucleotide polymorphisms (SNPs) in hydrochlorothiazideassociated genes and further assessed their correlation with blood pressure control among South African adults living with hypertension. ... -
Using a mHealth system to recall and refer existing clients and refer community members with health concerns to primary healthcare facilities in South Africa: a feasibility study
(Taylor & Francis, 2020)Background: Lay health workers (LHWs) are critical in linking communities and primary healthcare (PHC) facilities. Effective communication between facilities and LHWs is key to this role. We implemented a mobile health ... -
Novel South African rare actinomycete kribbella speibonae Strain SK5: A prolific producer of hydroxamate siderophores including new dehydroxylated congeners
(MDPI, 2020)In this paper, we report on the chemistry of the rare South African Actinomycete Kribbella speibonae strain SK5, a prolific producer of hydroxamate siderophores and their congeners. Two new analogues, dehydroxylated ... -
Assessment of Vancomycin Pharmacokinetics and Dose Regimen Optimisation in Preterm Neonates
(Springer Nature, 2020)The pharmacokinetics of vancomycin, a drug used for the treatment of methicillin-resistant Staphylococcus aureus (MRSA), varies between paediatric and adult patients. The objective of this study was to assess the ... -
Multistage antiplasmodial activity of hydroxyethylamine compounds,in vitroandin vivoevaluations
(Royal Society of Chemistry, 2020)Malaria, a global threat to the human population, remains a challenge partly due to the fast-growing drug-resistant strains of Plasmodium species. New therapeutics acting against the pathogenic asexual and sexual stages, ... -
Electrochemical studies of Pd-based anode catalysts in alkaline medium for direct glycerol fuel cells
(MDPI, 2020)his study investigates the most effective electrocatalyst for glycerol oxidation reaction (GOR) in alkaline medium for five synthesized electrocatalysts, Pd, PdNi, PdNiO, PdMn3O4 and PdMn3O4NiO, supported on multi-walled ... -
Synthesis, physicochemical characterization, toxicity and efficacy of a PEG conjugate and a hybrid PEG conjugate nanoparticle formulation of the antibiotic moxifloxacin
(Royal Society of Chemistry, 2020)Antibiotic resistance is increasing at such an alarming rate that it is now one of the greatest global health challenges. Undesirable toxic side-effects of the drugs lead to high rates of non-completion of treatment regimens ... -
Effects of alkali and transition metal-doped TiO2 hole blocking layers on the perovskite solar cells obtained by a two-step sequential deposition method in air and under vacuum
(Royal Society of Chemistry, 2020)Planar perovskite solar cells (PPSCs) have received great attention in recent years due to their intriguing properties, which make them a good choice for photovoltaic applications. In this work, the effect of alkali and ... -
Degradation of hydrocarbons and heavy metal reduction by marine bacteria in highly contaminated sediments
(MDPI, 2020)Investigations on the ability of bacteria to enhance removal of hydrocarbons and reduce heavy metal toxicity in sediments are necessary to design more effective bioremediation strategies. In this study, five bacterial ... -
Is there a link between the pathogenic human Coronavirus envelope protein and immunopathology? A review of the literature
(Frontiers Media S.A., 2020)Since the severe acute respiratory syndrome (SARS) outbreak in 2003, human coronaviruses (hCoVs) have been identified as causative agents of severe acute respiratory tract infections. Two more hCoV outbreaks have since ... -
Early-life gut dysbiosis linked to juvenile mortality in ostriches
(Springer Nature, 2020)Imbalances in the gut microbial community (dysbiosis) of vertebrates have been associated with several gastrointestinal and autoimmune diseases. However, it is unclear which taxa are associated with gut dysbiosis, and if ... -
Diverse genomoviruses representing twenty-nine species identified associated with plants
(Springer Nature, 2020)Genomoviruses (family Genomoviridae) are circular single-stranded DNA viruses that have been mainly identifed through metagenomics studies in a wide variety of samples from various environments. Here, we describe 98 genomes ... -
Towards characterising microplastic abundance, typology and retention in mangrove-dominated estuaries
(MPDI, 2020)Plastic and, particularly, microplastic (MP) pollution is a growing research theme, dedicated largely to marine systems. Occurring at the land–sea interface, estuarine habitats such as mangroves are at risk of plastic ... -
Alkaloids: Therapeutic Potential against Human Coronaviruses
(MPDI, 2020)Alkaloids are a class of natural products known to have wide pharmacological activity and have great potential for the development of new drugs to treat a wide array of pathologies. Some alkaloids have antiviral activity ...