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    Imino-quinolyl palladium(II) and platinum(II) complexes: synthesis, characterization, molecular structures and cytotoxic effect

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    Date
    2013
    Author
    Motswainyana, William M.
    Onani, Martin O.
    Madiehe, Abram M.
    Saibu, Morounke
    Jacobs, Jeroen
    van Meervelt, Luc
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    Abstract
    Imino-quinolyl ligands L1-L5 were synthesized by condensation reactions and obtained in good yields. Reactions of the ligands with either PdCl2(cod) or K2[PtCl4] gave the corresponding palladium(II) and platinum(II) complexes 1-10 also in good yields. All the compounds were characterized by elemental analysis, IR, 1H and 13C NMR spectroscopy. X-ray crystallography was used to confirm the structures of these compounds. Molecular structures of 3 and 5 showed that the ligands coordinate to the metal centre through the two nitrogen atoms, generating a distorted square planar geometry around the palladium atom. The new complexes exhibited remarkable cytotoxic activities against MCF-7 and HT-29 cancer cell lines.
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    http://hdl.handle.net/10566/1057
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    • Prof. Martin O Onani (Chemistry)
    • Research Articles (Chemistry)

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