Research Articles (IMBM): Recent submissions
Now showing items 1-20 of 35
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International nonproprietary names for monoclonal antibodies: an evolving nomenclature system
(Taylor and Francis, 2022)Appropriate nomenclature for all pharmaceutical substances is important for clinical development, licensing, prescribing, pharmacovigilance, and identification of counterfeits. Nonproprietary names that are unique and ... -
Nanotechnology advances towards development of targeted-treatment for obesity
(Journal of Nanobiotechnology, 2019)Obesity through its association with type 2 diabetes (T2D), cancer and cardiovascular diseases (CVDs), poses a serious health threat, as these diseases contribute to high mortality rates. Pharmacotherapy alone or in ... -
Cloning, expression and characterization of thermostable YdaP from Bacillus licheniformis 9A
(Acta Biochimica Polonica, 2017)The Bacillus licheniformis ydaP gene encodes for a pyruvate oxidase that catalyses the oxidative decarboxylation of pyruvate to acetate and CO2. The YdaP form of this enzyme was purified about 48.6-folds to homogeneity in ... -
Sputtered Si and Mg doped hydroxyapatite for biomedical applications
(IOP Publishing, 2018-01-30)Hydroxyapatite (HAP) coatings are applied on metallic implant materials to combine mechanical properties of metallic material with bioactivity abilities of HAP ceramic. In this study, HAP coatings with additions of Si ... -
Effect of Fe-Mo promoters on HZSM-5 zeolitecatalyst for 1-hexene aromatization
(Elsevier B.V., 2018-11-15)The promotional effect of Fe-Mo species introduced into HZSM-5 (Zeolyst Int.,SiO2/Al2O3 30) zeolite catalyst by the wetness impregnation method for the 1-hexene aromatiza-tion was investigated. The structure and catalytic ... -
Novel phages of healthy skin metaviromes from South Africa
(Nature Publishing Group, 2018)Recent skin metagenomic studies have investigated the harbored viral diversity and its possible influence on healthy skin microbial populations, and tried to establish global patterns of skin-phage evolution. However, ... -
Selection of diazotrophic bacterial communities in biological sand filter mesocosms used for the treatment of phenolic-laden wastewater
(Springer Verlag, 2013)Agri effluents such as winery or olive mill waste-waters are characterized by high phenolic concentrations. These compounds are highly toxic and generally refractory to biodegradation. Biological sand filters (BSFs) represent ... -
Engineering pyruvate decarboxylase-mediated ethanol production in the thermophilic host Geobacillus thermoglucosidasius
(Springer Verlag, 2013)This study reports the expression, purification, and kinetic characterization of a pyruvate decarboxylase (PDC) from Gluconobacter oxydans . Kinetic analyses showed the enzyme to have high affinity for pyruvate (120 μM at ... -
Hypolithic and soil microbial community assembly along an aridity gradient in the Namib Desert
(Springer, 2013)The Namib Dessert is considered the oldest desert in the world and hyperarid for the last 5 million years. However, the environmental buffering provided by quartz and other translucent rocks supports extensive hypolithic ... -
Selection of Clostridium spp. in biological sand filters neutralizing synthetic acid mine drainage
(Wiley, 2013)In this study, three biological sand filter (BSF) were contaminated with a synthetic iron- [1500 mg L-1 Fe(II), 500 mg L-1 Fe(III)] and sulphate-rich (6000 mg L-1 SO2/4-) acid mine drainage (AMD) (pH = 2), for 24 days, to ... -
Draft Genome Sequence of Gordonia lacunae BS2T
(American Society for Microbiology, 2017)We report here the draft genome sequence of the soil bacterium Gordonia lacunae BS2T ( DSM 45085T JCM 14873T NRRL B-24551T), isolated from an estuary in Plettenberg Bay, South Africa. Analysis of the draft genome ... -
Virome assembly and annotation: A surprise in the Namib Desert
(Frontiers Research Foundation, 2017)Sequencing, assembly, and annotation of environmental virome samples is challenging. Methodological biases and differences in species abundance result in fragmentary read coverage; sequence reconstruction is further ... -
Structure and functional characterization of pyruvate decarboxylase from Gluconacetobacter diazotrophicus
(BioMed Central, 2014)BACKGROUND: Bacterial pyruvate decarboxylases (PDC) are rare. Their role in ethanol production and in bacterially mediated ethanologenic processes has, however, ensured a continued and growing interest. PDCs from ... -
High-level diversity of tailed phages, eukaryote-associated viruses, and virophage-like elements in the metaviromes of Antarctic soils
(American Society for Microbiology, 2014)The metaviromes of two distinct Antarctic hyperarid desert soil communities have been characterized. Hypolithic communities, cyanobacterium-dominated assemblages situated on the ventral surfaces of quartz pebbles embedded ... -
A designed experiments approach to optimizing MALDI-TOF MS spectrum processing parameters enhances detection of antibiotic resistance in Campylobacter jejuni
(Frontiers Media, 2016)MALDI-TOF MS has been utilized as a reliable and rapid tool for microbial fingerprinting at the genus and species levels. Recently, there has been keen interest in using MALDI-TOF MS beyond the genus and species levels to ... -
Multilocus sequence typing methods for the emerging Campylobacter species C. hyointestinalis, C. lanienae, C. sputorum, C. concisus, and C. curvus
(Frontiers Media, 2012)Multilocus sequence typing (MLST) systems have been reported previously for multiple food - and food animal-associated Campylobacter species (e.g., C. jejuni, C. coli, C. lari, and C. fetus) to both differentiate strains ... -
Characterisation of campylobacter concisus strains from South Africa using amplified fragment length polymorphism (AFLP) profiling and a genomospecies-specific polymerase chain reaction (PCR) assay: Identification of novel genomospecies and correlation with clinical data
(Academic Journals, 2013)Amplified Fragment Length Polymorphism (AFLP) profiling was used to evaluate the distribution of phenotypically indistinguishable, but genetically distinct, among Campylobacter concisus strains from South Africa. A Polymerase ... -
Molecular characterization of the 16S rRNA Gene of helicobacter fennelliae isolated from stools and blood cultures from paediatric patients in South Africa
(Hindawi, 2011)Forty strains of H. fennelliae collected from paediatric blood and stool samples over an 18 year period at a children's hospital in Cape Town, South Africa, were amplified by PCR of the 16S rRNA. Two distinct genotypes ... -
Micro-Eukaryotic diversity in Hypolithons from Miers Valley, Antarctica
(Multidisciplinary Digital Publishing Institute (MDPI), 2013)The discovery of extensive and complex hypolithic communities in both cold and hot deserts has raised many questions regarding their ecology, biodiversity and relevance in terms of regional productivity. However, most ... -
Review and re-analysis of domain-specific 16S primers
(Elsevier, 2003)The Polymerase Chain Reaction (PCR) has facilitated the detection of unculturable microorganisms in virtually any environmental source and has thus been used extensively in the assessment of environmental microbial diversity. ...
