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Regulatory registration timelines of generic medicines in South Africa: Assessment of the performance of SAHPRA between 2011 and 2022
(Springer, 2023)
Various regulatory authorities are experiencing backlogs of applications which result in delayed access
to medicines for patients. The objective of this study is to critically assess the registration process utilised by ...
Zinc(ii) complex of (z)-4-((4-nitrophenyl)amino)pent-3-en-2-one, a potential antimicrobial agent: Synthesis, characterization, antimicrobial screening, dft calculation and docking study
(Chemical Society of Ethiopia, 2023)
Herein, the synthesis and characterizations of (Z)-4-((4-nitrophenyl)amino)pent-3-en-2-one (HL) ligand and its Zn(II) complex are reported. The compounds were characterized using elemental and thermogravimetric (TGA) ...
Documentation of antipsychotic-related adverse drug reactions: An educational intervention
(AOSIS, 2019)
Antipsychotic agents are associated with harmful adverse reactions which
impact negatively on patient adherence and clinical management. Accurate and complete
documentation of signs and symptoms in the clinical notes is ...
Synthesis of ester-linked ursolic acid-based hybrid compounds: Potential antibacterial and anticancer agents
(Wiley, 2023)
The molecular hybridization of two or more drugs into a single molecule is an effective drug design approach
to reduce pill burden and improve patient treatment adherence. Ursolic acid-based hybrid compounds were
synthesized ...
Tandem lc-ms identification of antitubercular compounds in zones of growth inhibition produced by South African filamentous actinobacteria
(MDPI, 2023)
Novel antitubercular compounds are urgently needed to combat drug-resistant Mycobacterium
tuberculosis (Mtb). Filamentous actinobacteria have historically been an excellent source of
antitubercular drugs. Despite this, ...
Preparation and evaluation of pralidoxime-loaded plga nanoparticles as potential carriers of the drug across the blood brain barrier
(Hindawi, 2015)
Pralidoxime is an organophosphate antidote with poor central nervous system distribution due to a high polarity. In the present
study, pralidoxime-loaded poly(lactic-co-glycolic acid) nanoparticles were prepared and ...