Browsing Research Articles (School of Pharmacy) by Author "Malan, Sarel, F"
Now showing items 1-3 of 3
-
Antimycobacterial Activity, Synergism, and Mechanism of Action Evaluation of Novel Polycyclic Amines against Mycobacterium tuberculosis
Kapp, Erika; Joubert, Jacques; Sampson, Samantha, L; Malan, Sarel, F; Sharma, Rajan; Warner, Digby, F; Seldon, Ronnett; Jordaan, Audrey; de Vos, Margaretha (Advances in Pharmacological and Pharmaceutical Sciences, 2021-06)Mycobacterium tuberculosis has developed extensive resistance to numerous antimycobacterial agents used in the treatment of tuberculosis. Insufficient intracellular accumulation of active moieties allows for selective ... -
Synthesis of 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as lead scaffolds for neuroprotective agents
Egunlusi, Ayodeji, O; Malan, Sarel, F; Joubert, Jacques (Arkivoc, 2020-09)Neurodegenerative disorders are characterised by progressive loss of neuronal functions. Of the proposed mechanisms, excitotoxicity, mediated by prolonged glutamate activation and calcium overload, is prominent. NGP1-01, ... -
Synthesis of 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as lead scaffolds for neuroprotective agents
Egunlusi, Ayodeji, O; Malan, Sarel, F; Joubert, Jacques (Arkivoc, 2020-09)Neurodegenerative disorders are characterised by progressive loss of neuronal functions. Of the proposed mechanisms, excitotoxicity, mediated by prolonged glutamate activation and calcium overload, is prominent. NGP1-01, ...