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Now showing items 111-120 of 150
Leopard tortoises in southern Africa have greater genetic diversity in the north than in the south (Testudinidae)
(Wiley, 2018)
In contrast to mammals, little is known about the phylogeographic structuring of widely distributed African reptile species. With the present study, we contribute data for the leopard tortoise (Stigmochelys pardalis). It ...
A post-market quality assessment of first-line, fixed-dose combination antiretrovirals in South Africa
(Journal of Applied Pharmaceutical Science, 2019)
South Africa has the world’s largest antiretroviral (ARV) program and despite having stringent upstream medicine’s
regulatory oversight, the post-market reassessment of ARV quality is prohibitively resource intensive. The ...
Comparative in vitro transportation of pentamidine across the blood-brain barrier using polycaprolactone nanoparticles and phosphatidylcholine liposomes
(UWC, 2019)
Nanoparticles (NPs) have gained importance in addressing drug delivery challenges across biological barriers. Here, we reformulated pentamidine, a drug used to treat Human African Trypanosomiasis (HAT) in polymer based ...
Bioprospecting of Helichrysum species: Chemical profile, phytochemical properties, and antifungal efficacy against botrytis cinerea
(MDPI, 2023)
Variation in plant species and extraction solvents play a crucial role in the recovery of
their bioactive compounds and antifungal efficacy. Thus, in this study, a comparative investigation
was carried out using extraction ...
In-silico and in-vivo evaluation of the cardiovascular effects of five Leonotis leonurus diterpenes
(Obikeze, K. et al. (2023). In-silico and in-vivo evaluation of the cardiovascular effects of five Leonotis leonurus diterpenes. Scientific African, 19, e01510. 10.1016/j.sciaf.2022.e01510, 2023)
Leonotis leonurus extracts and compounds have been extensively studied for pharmacological effects. However, most of the diterpenes isolated from the plant have not been evaluated as possible contributors to the cardiovascular ...
The implementation of a risk based assessment approach by the South African Health pProducts Regulatory Authority (SAHPRA)
(Springer, 2023)
An extensive backlog of pending regulatory decisions is one of the major historical challenges that the South
African Health Products Regulatory Authority (SAHPRA) inherited from the Medicine Control Council (MCC). Revising ...
Steady‐state population pharmacokinetics of terizidone and itsmetabolite cycloserine in patients with drug‐resistanttuberculosis
(Wiley, 2019)
Despite terizidone being part of the second‐line recommended drugs fortreatment of drug‐resistant tuberculosis (DR‐TB), information on its pharmacokineticsis scarce. The aim of this study was to describe the steady‐state ...
Green synthesized saunps as a potential delivery platform for cytotoxic alkaloids
(MDPI, 2023)
The use of natural products as chemotherapeutic agents is well established. However, many
are associated with undesirable side effects, including high toxicity and instability. Previous reports
on the cytotoxic activity ...
Exploring practising pharmacy graduates’ views on improving the effectiveness of pharmacy education at the University of the Western Cape, South Africa
(HEALTH & MEDICAL PUBLISHING GROUP, 2019)
South African health professional education institutions have a mandate to produce graduates who are able to address priority needs of the
healthcare system and larger society. However, evidence of the effective use of ...
Exploring the implications of a needs-based pharmacy education framework modelled on population health: Perspective from a developing country
(MDPI, 2019)
Globally, health education reform is directing efforts to strengthen the health system
through collaboration between health education and health services. However, collaborative efforts
vary between developed and developing ...