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Nanomedicines for infectious diseases
(Springer Nature, 2019)
Infectious diseases continue to pose a significant threat to global health. Over 200 infectious diseases are currently known to man. Fortunately, only a handful are responsible for significant morbidity and mortality. ...
Preceptor reflections on the Community Health clinical rotation for fourth year pharmacy students at the University of the Western Cape
(2019)
This paper describes the community health clinic rotation of the Patient Care Experience programme (PaCE) offered to fourth year pharmacy students (2018) at the University of the Western Cape. Reflections from the collective ...
Synthesis, Crystal Structure, DFT Studies, Docking Studies, and Fluorescent Properties of 2-(Adamantan-1-yl)-2H-isoindole-1-carbonitrile
(MDPI, 2019)
2-(Adamantan-1-yl)-2H-isoindole-1-carbonitrile (1) has been identified as a neurobiological fluorescent ligand that may be used to develop receptor and enzyme binding affinity assays. Compound 1 was synthesized using an ...
Structural analysis, molecular modelling and preliminary competition bnding studies of AM-DAN as a NMDA Receptor PCP-Site Fluorescent Ligand
(MDPI, 2019)
Excitotoxicity related to the dysfunction of the N-methyl-d-aspartate receptor (NMDAR)
has been indicated to play an integral role in the pathophysiology of multiple disease states, including
neurodegenerative disorders ...
A post-market quality assessment of first-line, fixed-dose combination antiretrovirals in South Africa
(Journal of Applied Pharmaceutical Science, 2019)
South Africa has the world’s largest antiretroviral (ARV) program and despite having stringent upstream medicine’s
regulatory oversight, the post-market reassessment of ARV quality is prohibitively resource intensive. The ...
Comparative in vitro transportation of pentamidine across the blood-brain barrier using polycaprolactone nanoparticles and phosphatidylcholine liposomes
(UWC, 2019)
Nanoparticles (NPs) have gained importance in addressing drug delivery challenges across biological barriers. Here, we reformulated pentamidine, a drug used to treat Human African Trypanosomiasis (HAT) in polymer based ...
Steady‐state population pharmacokinetics of terizidone and itsmetabolite cycloserine in patients with drug‐resistanttuberculosis
(Wiley, 2019)
Despite terizidone being part of the second‐line recommended drugs fortreatment of drug‐resistant tuberculosis (DR‐TB), information on its pharmacokineticsis scarce. The aim of this study was to describe the steady‐state ...
Exploring practising pharmacy graduates’ views on improving the effectiveness of pharmacy education at the University of the Western Cape, South Africa
(HEALTH & MEDICAL PUBLISHING GROUP, 2019)
South African health professional education institutions have a mandate to produce graduates who are able to address priority needs of the
healthcare system and larger society. However, evidence of the effective use of ...
Exploring the implications of a needs-based pharmacy education framework modelled on population health: Perspective from a developing country
(MDPI, 2019)
Globally, health education reform is directing efforts to strengthen the health system
through collaboration between health education and health services. However, collaborative efforts
vary between developed and developing ...
Amount of cycloserine emanating from terizidone metabolism and relationship with hepatic function in patients with drug resistant tuberculosis
(Springer, 2019)
The dosing of cycloserine and terizidone is the same, as both drugs are considered equivalent
or used interchangeably. Nevertheless, it is not certain from the literature that these drugs are interchangeable. Therefore,
the ...