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    Patient-Control Association Study of the Leucine-Rich Repeat Kinase 2 (LRRK2) Gene in South African Parkinson's Disease Patients

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    Bardien_ Patient-control association_2013.pdf (28.99Kb)
    Date
    2013
    Author
    Bardien, Soraya
    Blanckenberg, Janine
    van der Merwe, Lize
    Farrer, Matthew J.
    Ross, Owen A.
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    Abstract
    The leucine-rich repeat kinase 2 (LRRK2) gene is of interest to Parkinson's disease (PD) as it has been implicated in both familial and sporadic forms of the disorder.1 PD-susceptibility alleles in LRRK2 appear to be ethnic-specific with G2385R,2 R1628P3 and A419V4 identified in Asian populations, whereas M1646T is found in Caucasians.4 A haplotype protecting against development of PD is present in Chinese (N551K-R1398H)5 and Caucasians (N551K-R1398H-K1423K).4 Further studies are necessary to investigate the contribution of LRRK2 to PD-susceptibility in various populations worldwide.
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    http://hdl.handle.net/10566/3058
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