| dc.contributor.author | Bardien, Soraya | |
| dc.contributor.author | Blanckenberg, Janine | |
| dc.contributor.author | van der Merwe, Lize | |
| dc.contributor.author | Farrer, Matthew J. | |
| dc.contributor.author | Ross, Owen A. | |
| dc.date.accessioned | 2017-07-10T09:14:07Z | |
| dc.date.available | 2017-07-10T09:14:07Z | |
| dc.date.issued | 2013 | |
| dc.identifier.citation | Bardien, S. et al. (2013). Patient-Control Association Study of the Leucine-Rich Repeat Kinase 2 (LRRK2) Gene in South African Parkinson's Disease Patients. Movement Disorders, 28 (14): 1-4 | en_US |
| dc.identifier.issn | 0885-3185 | |
| dc.identifier.uri | http://hdl.handle.net/10566/3058 | |
| dc.description.abstract | The leucine-rich repeat kinase 2 (LRRK2) gene is of interest to Parkinson's disease (PD) as it
has been implicated in both familial and sporadic forms of the disorder.1 PD-susceptibility
alleles in LRRK2 appear to be ethnic-specific with G2385R,2 R1628P3 and A419V4
identified in Asian populations, whereas M1646T is found in Caucasians.4 A haplotype
protecting against development of PD is present in Chinese (N551K-R1398H)5 and
Caucasians (N551K-R1398H-K1423K).4 Further studies are necessary to investigate the
contribution of LRRK2 to PD-susceptibility in various populations worldwide. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | National Institute of Health | en_US |
| dc.rights | This is the author-version of the article published online at: http://dx.doi.org/doi:10.1002/mds.25637 | |
| dc.source.uri | http://dx.doi.org/doi:10.1002/mds.25637 | |
| dc.subject | Parkinson’s disease | en_US |
| dc.subject | LRRK2 gene | en_US |
| dc.subject | Case-control association studies | en_US |
| dc.subject | South African population | en_US |
| dc.title | Patient-Control Association Study of the Leucine-Rich Repeat Kinase 2 (LRRK2) Gene in South African Parkinson's Disease Patients | en_US |
| dc.type | Article | en_US |
| dc.description.accreditation | Department of HE and Training approved list | |
