Pharmaceutical co-crystal: An alternative strategy for enhanced physicochemical properties and drug synergy
Abstract
A growing number of co-crystals in the literature are proof of how significant
the co-crystallization concept has become. Co-crystallization enhances
physicochemical properties through the formation of intermolecular interactions
between a drug and a co-former. A co-crystal is a single crystalline material
consisting of at least two molecular components solid at room temperature and
present in a definite stoichiometric ratio. Pharmaceutical co-crystals consist of
the active pharmaceutical ingredient and the co-former selected from generally
regarded as safe (GRAS) list of the United State Food and Drug Administration.
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