Browsing Research Articles (SANBI) by Title
Now showing items 110-127 of 127
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Symptom evolution following the emergence of maize streak virus
(eLife Sciences Publications, 2020)For pathogens infecting single host species evolutionary trade-offs have previously been demonstrated between pathogen-induced mortality rates and transmission rates. It remains unclear, however, how such trade-offs ... -
Synthesis of oxygen deficient tio2 for improved photocatalytic efficiency in solar radiation
(MDPI, 2021)The photocatalytic activities of TiO2 have been limited mainly to absorbing in the ultraviolet spectrum which accounts for only 5% of solar radiation. High energy band gap and electron recombination in TiO2 nanoparticles ... -
SysBiolPGWAS: Simplifying post-GWAS analysis through the use of computational technologies and integration of diverse omics datasets
(Oxford University Press, 2023)Post-genome-wide association studies (pGWAS) analysis is designed to decipher the functional consequences of significant single-nucleotide polymorphisms (SNPs) in the era of GWAS. This can be translated into research ... -
SysBiolPGWAS: simplifying post-GWAS analysis through the use of computational technologies and integration of diverse omics datasets
(Bioinformatics, 2022)Motivation: Post-genome-wide association studies (pGWAS) analysis is designed to decipher the functional consequences of significant single-nucleotide polymorphisms (SNPs) in the era of GWAS. This can be translated into ... -
Taste and odorant receptors of the coelecanth- a gene repertoire in transition
(Wiley, 2014)G-protein coupled chemosensory receptors (GPCR-CRs) aid in the perception of odors and tastes in vertebrates. So far, six GPCR-CR families have been identified that are conserved in most vertebrate species. Phylogenetic ... -
Ten simple rules for developing bioinformatics capacity at an academic institution
(Public Library of Science, 2021)Bioinformatics is an applied interdisciplinary field whose primary purpose is to develop and deploy computational techniques to store, organize, and aid in the analysis and interpretation of large-scale data obtained ... -
Transcriptomic analysis reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain
(Plosone, 2008)Our knowledge on zebrafish reproduction is very limited. We generated a gonad-derived cDNA microarray from zebrafish and used it to analyze large-scale gene expression profiles in adult gonads and other organs. We have ... -
Transcriptomic profile of mycobacterium smegmatis in response to an imidazo[1,2-b][1,2,4,5]tetrazine reveals its possible impact on iron metabolism
(Frontiers Media, 2021)Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex bacteria, is one of the most pressing health problems. The development of new drugs and new therapeutic regimens effective against the pathogen is one ... -
Transforming RNA-Seq gene expression to track cancer progression in the multi-stage early to advanced-stage cancer development
(Public Library of Science, 2023)Cancer progression can be tracked by gene expression changes that occur throughout early-stage to advanced-stage cancer development. The accumulated genetic changes can be detected when gene expression levels in advanced-stage ... -
Trends in Genotypic HIV-1 Antiretroviral resistance between 2006 and 2012 in South African Patients receiving first- and second line antiretroviral treatment regimens
(University of the Western CapePublic Library of Science -- PLoS, 2013)South Africa's national antiretroviral (ARV) treatment program expanded in 2010 to include the nucleoside reverse transcriptase (RT) inhibitors (NRTI) tenofovir (TDF) for adults and abacavir (ABC) for children. We ... -
Understanding biobanking : An assessment of the public engagement speaking book intervention Biobanking and Me
(South African Medical Association, 2019)Meaningful engagement with donors of biological samples intended for human-sample biobanking increases knowledge, and allows donors to make informed decisions. Informed donors provide a platform for public awareness, ... -
Unveiling the inhibitory potentials of peptidomimetic azanitriles and pyridyl esters towards sars-cov-2 main protease: a molecular modelling investigation
(MDPI, 2023)The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for COVID-19, which was declared a global pandemic in March 2020 by the World Health Organization (WHO). Since SARS-CoV-2 main protease plays ... -
Using multiplex amplicon pcr technology to efficiently and timely generate rift valley fever virus sequence data for genomic surveillance
(MDPI, 2023)Rift Valley fever (RVF) is a febrile vector-borne disease endemic in Africa and continues to spread in new territories. It is a climate-sensitive disease mostly triggered by abnormal rainfall patterns. The disease is ... -
Variant-specific introduction and dispersal dynamics of SARS-CoV-2 in New York City – from Alpha to Omicron
(Public Library of Science, 2023)Since the latter part of 2020, SARS-CoV-2 evolution has been characterised by the emergence of viral variants associated with distinct biological characteristics. While the main research focus has centred on the ability ... -
A view on genomic medicine activities in Africa: Implications for policy
(Frontiers Media, 2022)Genomics policy development involves assessing a wide range of issues extending from specimen collection and data sharing to whether and howto utilize advanced technologies in clinical practice and public health initiatives. ... -
Virome assembly and annotation: A surprise in the Namib Desert
(Frontiers Research Foundation, 2017)Sequencing, assembly, and annotation of environmental virome samples is challenging. Methodological biases and differences in species abundance result in fragmentary read coverage; sequence reconstruction is further ... -
The westward journey of alfalfa leaf curl virus
(MDPI, 2018)Alfalfa leaf curl virus (ALCV), which causes severe disease symptoms in alfalfa (Medicago sativa L.) and is transmitted by the widespread aphid species, Aphis craccivora Koch, has been found throughout the Mediterranean ... -
Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans
(Nature Publishing Group, 2017)The Southern African Human Genome Programme is a national initiative that aspires to unlock the unique genetic character of southern African populations for a better understanding of human genetic diversity. In this pilot ...
