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Functional and structural analysis of predicted proteins obtained from homo sapiens' minisatellite 33.15-tagged transcript pAKT-45 variants
(Hindawi, 2020)
The spermatozoa are transcriptionally dormant entities which have been recognized to be an archive of mRNA, coding for a variety of functionally crucial cellular proteins. This significant repository of mRNA is predicted ...
Ellagic acid controls cell proliferation and induces apoptosis in breast cancer cells via inhibition of cyclin-dependent kinase 6
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
Cyclin-Dependent Kinase 6 (CDK6) plays an important role in cancer progression, and thus, it is considered as an attractive drug target in anticancer therapeutics. This study presents an evaluation of dietary phytochemicals, ...
Identification of novel prognostic markers of survival time in high-risk neuroblastoma using gene expression profiles
(Impact Journals, 2020)
Neuroblastoma is the most common extracranial solid tumor in childhood. Patients in high-risk group often have poor outcomes with low survival rates despite several treatment options. This study aimed to identify a genetic ...
Genome sequencing of a severe acute respiratory syndrome Coronavirus 2 isolate obtained from a South African patient with Coronavirus disease 2019
(American Society for Microbiology, 2020)
As a contribution to the global efforts to track and trace the ongoing coronavirus pandemic, here we present the sequence, phylogenetic analysis, and modeling of nonsynonymous mutations for a severe acute respiratory ...
Cellular and molecular targets of waterbuck repellent blend odors in antennae of glossina fuscipes fuscipes newstead, 1910
(Frontiers Media S.A., 2020)
Insects that transmit many of the world’s deadliest animal diseases, for instance
trypanosomosis, find their suitable hosts and avoid non-preferred hosts mostly through
olfactory cues. The waterbuck repellent blend (WRB) ...
Intact HIV proviruses persist in children seven to nine years after initiation of antiretroviral therapy in the first year of life
(American Society for Microbiology, 2020)
In adults starting antiretroviral therapy (ART) during acute infection, 2% of proviruses that persist on ART are genetically intact by sequence analysis. In contrast, a recent report in children treated early failed to ...
Structural and molecular docking analytical studies of the predicted ligand binding sites of cadherin-1 in cancer prognostics
(Dove Medical Press, 2020)
Several studies have explored the design of antimicrobial peptides (AMPs) for the
development of therapeutic and diagnostic molecules for the treatment and identification of
pathogenic diseases as well as cancer. Human ...
COMBAT-TB-NeoDB: Fostering tuberculosis research through integrative analysis using graph database technologies
(Oxford University Press, 2020)
Tuberculosis (TB) is a significant global health threat, with onethird of the population infected with its causative agent
Mycobacterium tuberculosis (M.tb). Globally, researchers have been
responding with a plethora of ...
Symptom evolution following the emergence of maize streak virus
(eLife Sciences Publications, 2020)
For pathogens infecting single host species evolutionary trade-offs have previously
been demonstrated between pathogen-induced mortality rates and transmission rates. It remains
unclear, however, how such trade-offs ...
Information security at South African universities-Implications for biomedical research
(Oxford University Press, 2020)
In South Africa, a similar regulation strategy to
the European Union General Data Protection
Regulation, called the Protection of Personal
Information Act (No 4 of 2013) (POPIA), will be
implemented, with a view to ...