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Now showing items 31-39 of 39
Emerging evidence implicating a role for neurexins in neurodegenerative and neuropsychiatric disorders
(The Royal Society, 2021)
Synaptopathies are brain disorders characterized by dysfunctional synapses,
which are specialized junctions between neurons that are essential for the transmission of information. Synaptic dysfunction can occur due to ...
Ten simple rules for developing bioinformatics capacity at an academic institution
(Public Library of Science, 2021)
Bioinformatics is an applied interdisciplinary field whose primary purpose is to develop and
deploy computational techniques to store, organize, and aid in the analysis and interpretation
of large-scale data obtained ...
Dispersal dynamics of SARS-CoV-2 lineages during the first epidemic wave in New York City
(Public Library of Science, 2021)
During the first phase of the COVID-19 epidemic, New York City rapidly became the epicenter of the pandemic in the United States. While molecular phylogenetic analyses have previously highlighted multiple introductions and ...
A novel nano therapeutic using convalescent plasma derived exosomal (CPExo) for Covid-19: A combined hyperactive immune modulation and diagnostics
(Elsevier, 2021)
Extracellular vesicles like exosomes are important therapeutic tactics for treating COVID -19. By utilizing
convalescent plasma derived exosomes (CPExo) from COVID-19 recovered persistence could accelerate the
treatment ...
In silico repurposing of a Novobiocin derivative for activity against latency associated Mycobacterium tuberculosis drug target nicotinate-nucleotide adenylyl transferase (Rv2421c)
(Public Library of Science, 2021)
Nicotinamide-nucleotide adenylyl transferase (Rv2421c) was selected as a potential drug
target, because it has been shown, in vitro, to be essential for Mycobacterium tuberculosis
growth. It is conserved between mycobacterium ...
Computational approaches for the design of novel anticancer compounds based on pyrazolo[3,4-d]pyrimidine derivatives as trap1 inhibitor
(Switzerland: MDPI AG, 2021)
In the present in-silico study, various computational techniques were applied to determine potent compounds against TRAP1 kinase. The pharmacophore hypothesis DHHRR_1 consists of important features required for activity. ...
Computational approaches for the design of novel anticancer compounds based on pyrazolo[3,4-d]pyrimidine derivatives as trap1 inhibitor
(MPDI, 2021)
In the present in-silico study, various computational techniques were applied to determine
potent compounds against TRAP1 kinase. The pharmacophore hypothesis DHHRR_1 consists of
important features required for activity. ...
Exploring new genetic variants within col5a1 intron 4‐exon 5 region and tgf‐β family with risk of anterior cruciate ligament ruptures
(Wiley, 2020)
Variants within genes encoding structural and regulatory elements of ligaments have
been associated with musculoskeletal soft tissue injury risk. The role of intron 4‐exon
5 variants within the α1 chain of type V collagen ...
Predicting amplification of mycn using cpg methylation biomarkers in neuroblastoma
(Future Science Group, 2021)
Neuroblastoma is the most common extracranial solid tumor in childhood. Amplification of MYCN in neuroblastoma is a predictor of poor prognosis. Materials and methods: DNA methylation data from the TARGET data matrix were ...