Browsing Prof. Alan Christoffels by Title
Now showing items 1-19 of 19
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The African Coelecanth genome provides insights into tetrapod evolution
(Macmillan Publishers, 2013)The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of ... -
Comparative analysis of testis and ovary transcriptomes in zebrafish by combining experimental and computational tools
(Wiley, 2004)Studies on the zebrafish model have contributed to our understanding of several important developmental processes, especially those that can be easily studied in the embryo. However, knowledge on late events such as gonad ... -
DAMPD: a manually curated antimicrobial peptide database
(Oxford University Press, 2012)The demand for antimicrobial peptides (AMPs) is rising because of the increased occurrence of pathogens that are tolerant or resistant to conventional antibiotics. Since naturally occurring AMPs could serve as templates ... -
Evolution and structural analysis of Glossina morsitans (Diptera; Glossinidae) Tetraspanins
(MDPI, Basel, Switzerland, 2014)Tetraspanins are important conserved integral membrane proteins expressed in many organisms. Although there is limited knowledge about the full repertoire, evolution and structural characteristics of individual members ... -
Genome sequence of the tsetse fly (glossina morsitans): vector of African trypanosomiasis
(American Association for the Advancement of Science, 2014)Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between ... -
Genome-wide SNP identification by high-throughput sequencing and selective mapping allows sequence assembly positioning using a framework genetic linkage map
(BioMed Central, 2010)Determining the position and order of contigs and scaffolds from a genome assembly within an organism’s genome remains a technical challenge in a majority of sequencing projects. In order to exploit contemporary technologies ... -
A glance at quality score: implication for de novo transcriptome reconstruction of Illumina reads
(Frontiers, 2014)Downstream analyses of short-reads from next-generation sequencing platforms are often preceded by a pre-processing step that removes uncalled and wrongly called bases. Standard approaches rely on their associated base ... -
Gonad differentiation in zebrafish is regulated by the canonical Wnt signalling pathway
(Society for the Study of Reproduction, 2014)Zebrafish males undergo a ‘‘juvenile ovary-to-testis’’ gonadal transformation process. Several genes, including nuclear receptor subfamily 5, group A (nr5a) and anti-Mu¨ llerian hormone (amh), and pathways such as Tp53-mediated ... -
Human African trypanosomiasis research gets booost: unravelling the tsetse Genome
(PLOS, 2014)Human African trypanosomiasis (HAT), also known as sleeping sickness, is a neglected disease that impacts 70 million people distributed over 1.55 million km2 in sub-Saharan Africa. Trypanosoma brucei gambiense accounts for ... -
Inferring bona fide transfrags in RNA-Seq derived-transcriptome assemblies of non-model organisms
(BioMed Central, 2015)Background: De novo transcriptome assembly of short transcribed fragments (transfrags) produced from sequencing-by-synthesis technologies often results in redundant datasets with differing levels of unassembled, partially ... -
An integrated and comparative approach towards identification, characterization and functional annotation of candidate genes for drought tolerance in sorghum (Sorghum bicolor (L.) Moench)
(BioMed Central, 2017)BACKGROUND: Drought is the most disastrous abiotic stress that severely affects agricultural productivity worldwide. Understanding the biological basis of drought-regulated traits, requires identification and an in-depth ... -
International Glossina Genome Initiative 2004-2014: a driver for post-genomic era research on the African continent
(PLOS, 2014)Human African trypanosomiasis (HAT), also known as sleeping sickness, is a neglected disease that impacts 70 million people distributed over 1.55 million km2 in sub- Saharan Africa and includes at least 50% of the population ... -
Mice and men: Their promoter properties
(PLoS Genetics, 2006)Using the two largest collections of Mus musculus and Homo sapiens transcription start sites (TSSs) determined based on CAGE tags, ditags, full-length cDNAs, and other transcript data, we describe the compositional landscape ... -
Molecular evolution of key receptor genes in primates and non-human primates
(Science Publishing Group, 2014)African primates remain an unexplored source of information required to complete the origin and evolution of many human pathogens. Current studies have shown the importance of several receptor human genes implicated in ... -
Odorant and gustatory receptors in the tsetse fly Glossina morsitans morsitans
(PLOS, 2014)Tsetse flies use olfactory and gustatory responses, through odorant and gustatory receptors (ORs and GRs), to interact with their environment. Glossina morsitans morsitans genome ORs and GRs were annotated using homologs ... -
Taste and odorant receptors of the coelecanth- a gene repertoire in transition
(Wiley, 2014)G-protein coupled chemosensory receptors (GPCR-CRs) aid in the perception of odors and tastes in vertebrates. So far, six GPCR-CR families have been identified that are conserved in most vertebrate species. Phylogenetic ... -
Transcriptomic analysis reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain
(Plosone, 2008)Our knowledge on zebrafish reproduction is very limited. We generated a gonad-derived cDNA microarray from zebrafish and used it to analyze large-scale gene expression profiles in adult gonads and other organs. We have ... -
A uniquely African focus: bioinformatics is a field that has grown exponentially in the past few years, and it is becoming increasingly important to collaborate as the field continues to gather momentum
(2015)Bioinformatics is a field that has grown exponentially in the past few years, and it is becoming increasingly important to collaborate as the field continues to gather momentum. -
Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans
(Nature Publishing Group, 2017)The Southern African Human Genome Programme is a national initiative that aspires to unlock the unique genetic character of southern African populations for a better understanding of human genetic diversity. In this pilot ...