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dc.contributor.authorRahiman, Farzana
dc.contributor.authorPool, Edmund John
dc.date.accessioned2017-09-12T10:11:58Z
dc.date.available2017-09-12T10:11:58Z
dc.date.issued2013
dc.identifier.citationRahiman, F. & Pool, E.D. (2013). The in vitro effects of artificial and natural sweeteners on the immune system using whole blood culture assays. Journal of Immunoassay and Immunochemistry, 35(1): 26-36en_US
dc.identifier.issn1532-1819
dc.identifier.urihttp://dx.doi.org/10.1080/15321819.2013.784197
dc.identifier.urihttp://hdl.handle.net/10566/3189
dc.description.abstractThis article investigates the effects of commercially available artificial (aspartame, saccharin, sucralose) and natural sweeteners (brown sugar, white sugar, molasses) on the immune system. Human whole blood cultures were incubated with various sweeteners and stimulated in vitro with either phytohemagglutinin or endotoxin. Harvested supernatants were screened for cytotoxicity and cytokine release. Results showed that none of the artificial or natural sweeteners proved to be cytotoxic, indicating that no cell death was induced in vitro. The natural sweetener, sugar cane molasses (10 ug=mL), enhanced levels of the inflammatory biomarker IL-6 while all artificial sweeteners (10 ug=mL) revealed a suppressive effect on IL-6 secretion (P<0.001). Exposure of blood cells to sucralose-containing sweeteners under stimulatory conditions reduced levels of the biomarker of humoral immunity, Interleukin-10 (P<0.001). The cumulative suppression of Interleukin-6 and Interleukin-10 levels induced by sucralose may contribute to the inability in mounting an effective humoral response when posed with an exogenous threat.en_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.rightsThis is the author-version of the article published online at: http://dx.doi.org/10.1080/15321819.2013.784197
dc.subjectBiomarkersen_US
dc.subjectCellular immunityen_US
dc.subjectCytokinesen_US
dc.subjectHuman whole blood culturesen_US
dc.subjectHumoral immunityen_US
dc.subjectSweetenersen_US
dc.titleThe in vitro effects of artificial and natural sweeteners on the immune system using whole blood culture assaysen_US
dc.typeArticleen_US
dc.privacy.showsubmitterFALSE
dc.status.ispeerreviewedTRUE
dc.description.accreditationWeb of Science


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