The department fields specific expertise within the broad research fields of Anatomy, Cardiovascular Physiology, Herbal Sciences, Immunology, Medical Microbiology, Molecular & Cell Biology, Neuroscience, Reproduction, Toxicology and Virology

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Recent Submissions

  • Radiations and male fertility 

    Kesari, Kavindra Kumar; Agarwal, Ashok; Henkel, Ralf (Springer Nature, 2018)
    During recent years, an increasing percentage of male infertility has to be attributed to an array of environmental, health and lifestyle factors. Male infertility is likely to be affected by the intense exposure to heat ...
  • Antioxidant and apoptosis-inhibition potential of Carpobrotus edulis in a model of parkinson’s disease 

    Enogieru, A.B.; Omoruyi, S.I.; Ekpo, Okobi (African Association of Physiological Sciences, 2018)
    Background: Parkinson’s disease (PD) is a neurological disorder resulting from the progressive loss of dopaminergic neurons. There is currently no known cure for PD, thus the search for complementary and alternative medicines ...
  • K21 compound, a potent antifungal agent: Implications for the treatment of fluconazole-resistant HIV-associated Candida species 

    John, Cathy Nisha; Abrantes, Pedro Miguel dos Santos; Prusty, Bhupesh; Ablashi, Dharam; Africa, Charlene Wilma Joyce (Frontiers, 2019-05-24)
    Background/objectives: With mucocutaneous candidiasis being highly prevalent in HIV patients, the emergence of fluconazole-resistant Candida species forms a major challenge in treating and eradicating these infections. The ...
  • Eco-friendly synthesis, characterization, in vitro and in vivo anti-inflammatory activity of silver nanoparticle-mediated Selaginella myosurus aqueous extract 

    Kedi, Philippe Belle Ebanda; Meva, Francois Eya’ane; Kotsedi, Lebogang; Nguemfo, Edwige Laure; Zangueu, Calvin Bogning; Ntoumba, Agnes Antoinette; Mohamed, Hamza Elsayed Ahmed; Dongmo, Alain Bertrand; Maaza, Malik (Dovepress, 2018)
    Introduction: There is emerging interest in medicinal plants in the biomedical field, due to their multitude of chemicals which show anti-inflammatory, antimicrobial, antiviral, or antitumoral potential. Research on ...
  • Acute toxicity studies of the South African medicinal plant Galenia africana 

    Ng’uni, Tiza; Klaasen, Jeremy A.; Fielding, Burtram C. (Elsevier, 2018)
    Background: Medicinal plants are used by a large proportion of the global population as complementary and alternative medicines. However, little is known about their toxicity. G. africana has been used to treat wounds, coughs ...
  • Carica papaya seed extract slows human sperm 

    Ghaffarilaleh, Vahid; Fisher, David; Henkel, Ralf (Elsevier, 2019)
    Ethnopharmacological relevance: Traditional healers use Carica papaya seeds as a remedy for diseases and as a contraceptive for men and abortion in women. Material and methods: Semen samples from 35 healthy men were allowed ...
  • Oral health status and treatment needs of pregnant women attending antenatal clinics in KwaZulu-Natal, South Africa 

    Africa, Charlene Wilma Joyce; Turton, Mervyn (Hindawi, 2019)
    During pregnancy, the oral cavity is characterised by an acidic environment and an inflammatory response brought about by vomiting and changes in hormonal levels, respectively, thereby increasing the mother’s risk of ...
  • Colistin, Carbapenem and Cephalosporin-resistant Klebsiella pneumoniae reported from Misrata, Libya 

    Shallouf, Mohamed; Abrantes, Pedro Miguel dos Santos; Fielding, Burtram Clinton; Africa, Charlene Wilma Joyce (Medpharm Publications, 2017)
    Background: National surveillance of antimicrobial resistance has become a mandatory approach to control the spread of antimicrobial resistance and for the establishment of antibiotic treatment guidelines. In this study, ...
  • Candida species carriage in diabetic patients in Misrata, Libya 

    Esmaio, Mustafa Hassan Mustafa; Abrantes, Pedro Miguel dos Santos; Africa, Charlene Wilma Joyce (Medpharm Publications, 2017)
    Background: There is a paucity of studies describing the prevalence and antimicrobial profiles of Candida in Libya. Limited treatment choices in the antifungal armamentarium in public healthcare settings in Africa require ...
  • Vitek characterisation of type 2 diabetes-associated Candida species 

    Esmaio, Mustafa Hassan Mustafa; Abrantes, Pedro Miguel dos Santos; Africa, Charlene Wilma Joyce (Elsevier, 2017)
    Background: Type 2 diabetes mellitus (T2DM) predisposes patients to opportunistic infections, such as invasive candidiasis. Treatment of candidiasis is challenged by the emerging resistance of Candida species. In this ...
  • Group B streptococcus serotypes in pregnant women from the Western Cape region of South Africa 

    Africa, Charlene Wilma Joyce; Kaambo, Eveline (Frontiers, 2018-12-04)
    Background: Maternal colonization of Group B streptococci (GBS) during pregnancy is an important risk factor for neonatal morbidity and mortality. The aim of this study was to determine the prevalence and serotype distribution ...
  • An in-depth bibliometric analysis and current perspective on male infertility research 

    Baskaran, Saradha; Agarwal, Ashok; Leisegang, Kristian; Peter, Natesan Pushparaj; Selvam, Manesh Kumar Panner; Henkel, Ralf (Korean Society for Sexual Medicine and Andrology, 2019)
    PURPOSE: Male infertility is emerging as a major, escalating global health problem that imposes the need to investigate research trends in male infertility. The purpose of this study is to analyze male infertility research ...
  • B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients 

    Flepisi, Brian T.; Bouic, Patrick; Sissolak, Gerhard; Rosenkranz, Bernd (AOSIS, 2018)
    BACKGROUND: Altered immune mechanisms play a critical role in the pathogenesis of non- Hodgkin’s lymphoma (NHL). HIV-1 (HIV) infection is associated with a state of excessive T-cell activation, which can lead to increased ...
  • Microtubular dysfunction and male infertility 

    Gunes, Sezgin; Sengupta, Pallav; Henkel, Ralf; Alguraigari, Aabed; Sinigaglia, Mariana Marques; Kayal, Malik; Joumah, Ahmad; Agarwal, Ashok (Korean Society for Sexual Medicine and Andrology, 2018)
    Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain ...
  • The excessive use of antioxidant therapy: A possible cause of male infertility? 

    Henkel, Ralf; Sandhu, Inderpreet Singh; Agarwal, Ashok (Wiley, 2018)
    Reactive oxygen species and oxidative stress are closely associated with various pathologies such as neurodegenerative diseases, ageing and male infertility. Hence, antioxidants such as vitamin C, vitamin E, N‐acetyl ...
  • Smoking‐induced genetic and epigenetic alterations in infertile men 

    Gunes, Sezgin; Mahmutoglu, Asli Metin; Arslan, Mehmet Alper; Henkel, Ralf (Wiley, 2018)
    Male fertility rates have shown a progressive decrease in both developing and industrialised countries in the past 50 years. Clinical and epidemiological studies have demonstrated controversial results about the harmful ...
  • Reactive oxygen species and male reproductive hormones 

    Darbandi, Mahsa; Darbandi, Sara; Agarwal, Ashok; Sengupta, Pallav; Durairajanayagam, Damayanthi; Henkel, Ralf; Sadeghi, Mohammad Reza (BMC, 2018)
    Reports of the increasing incidence of male infertility paired with decreasing semen quality have triggered studies on the effects of lifestyle and environmental factors on the male reproductive potential. There are ...
  • Quantitative assessment of heavy metal effects on sperm function using computer‐aided sperm analysis and cytotoxicity assays 

    Hardneck, Farren; Israel, Gadieja; Pool, Edmund; Maree, Liana (Wiley, 2018)
    One known environmental risk factor impacting on human reproduction is heavy metal pollution. Although some metals (e.g., Cu, Se and Zn) have protective effects on the male reproductive system in low doses, heavy metals ...
  • Reactive oxygen species and male reproductive hormones 

    Darbandi, Mahsa; Darbandi, Sara; Agarwal, Ashok; Sengupta, Pallav; Durairajanayagam, Damayanthi; Henkel, Ralf; Sadeghi, Mohammad Reza (BMC, 2018)
    Reports of the increasing incidence of male infertility paired with decreasing semen quality have triggered studies on the effects of lifestyle and environmental factors on the male reproductive potential. There are ...
  • Rutin as a potent antioxidant: implications for neurodegenerative disorders 

    Enogieru, Adaze Bijou; Haylett, William; Hiss, Donavon Charles; Bardien, Soraya; Ekpo, Okobi Eko (Hindawi Publishing Corporation, 2018)
    A wide range of neurodegenerative diseases (NDs), including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and prion diseases, share common mechanisms such as neuronal loss, apoptosis, mitochondrial ...

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