Task-sharing of psychological treatment for antenatal depression in Khayelitsha, South Africa: Effects on antenatal and postnatal outcomes in an individual randomised controlled trial
Date
2020Author
Lund, Crick
Schneider, Marguerite
Garman, Emily C
Davies, Thandi
Munodawafa, Memory
Honikman, Simone
Bhana, Arvin
Bassf, Judith
Bolton, Paul
Dewey, Michael
Joska, John
Kagee, Ashraf
Myer, Landon
Petersen, Inge
Prince, Martin
Stein, Dan J
Tabana, Hanani
Thornicroft, Graham
Tomlinson, Mark
Hanlon, Charlotte
Alem, Atalay
Susser, Ezra
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The study's objective was to determine the effectiveness of a task-sharing psychological treatment for perinatal depression using non-specialist community health workers. A double-blind individual randomised controlled trial was conducted in two antenatal clinics in the peri-urban settlement of Khayelitsha, Cape Town. Adult pregnant women who scored 13 or above on the Edinburgh Postnatal Depression rating Scale (EPDS) were randomised into the intervention arm (structured six-session psychological treatment) or the control arm (routine antenatal health care and three monthly phone calls). The primary outcome was response on the Hamilton Depression Rating Scale (HDRS) at three months postpartum (minimum 40% score reduction from baseline) among participants who did not experience pregnancy or infant loss (modified intention-to-treat population) (registered on Clinical Trials: NCT01977326).