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Are claudin-5 tight-junction proteins in the blood-brain barrier porous?
(Wolters Kluwer Health, 2020)
The capillaries of the brain are particularly special, as they are not
simply conduits for blood, but are primarily responsible to ensure that
the neurons function in a strictly regulated homeostatic interstitium.
Brain ...
High-resolution insights into the in vitro developing blood-brain barrier: Novel morphological features of endothelial nanotube function
(Frontiers Media, 2021)
High-resolution electron microscopy (HREM) imaging of the in vitro blood-brain barrier
(BBB), is a promising modality for investigating the dynamic morphological interplay
underpinning BBB development. The successful ...
The Ism between endothelial cilia and endothelial nanotubules is an evolving concept in the genesis of the BBB
(MDPI, 2022)
The blood–brain barrier (BBB) is fundamental in maintaining central nervous system (CNS)
homeostasis by regulating the chemical environment of the underlying brain parenchyma. Brain
endothelial cells (BECs) constitute ...
Exosomes form tunneling nanotubes (TUNTs) in the blood-brain barrier: A nano-anatomical perspective of barrier genesis
(Frontiers Media, 2022)
The blood-brain barrier (BBB) is a robust interface between the blood
and the central nervous system. Barrier type endothelium is able to limit
paracellular (PC) movement, relegating molecular flux to the transendothel ...
Next generation precision medicine: Crispr-mediated genome editing for the treatment of neurodegenerative disorders
(Springerlink, 2019)
Despite significant advancements in the field of molecular neurobiology especially neuroinflammation and neurodegeneration, the highly complex molecular mechanisms underlying neurodegenerative diseases remain elusive. As ...