Browsing Research Articles (Medical Bioscience) by Title
Now showing items 14-33 of 270
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Aqueous leaf extract of Moringa oleifera reduced intracellular ROS production, DNA fragmentation and acrosome reaction in Human spermatozoa in vitro
(Blackwell Publishing Ltd, 2021)The effects of aqueous leaf extract of Moringa oleifera (MO) on human sperm functions and integrity was studied in vitro. Semen was obtained by masturbation after 3–5 days' abstinence from 34 healthy donors in Western Cape, ... -
Aqueous leaf extract of Sutherlandia frutescens attenuates ROS-induced apoptosis and loss of mitochondrial membrane potential in MPP+-treated SH-SY5Y cells
(University of Benin, 2020)To investigate the neuroprotective activity of the aqueous extract of Sutherlandia frutescens (SF) against 1-methyl-4-phenylpyridinium (MPP+)-induced toxicity in SH-SY5Y neuroblastoma cells. Methods: SH-SY5Y neuroblastoma ... -
Are claudin-5 tight-junction proteins in the blood-brain barrier porous?
(Wolters Kluwer Health, 2020)The capillaries of the brain are particularly special, as they are not simply conduits for blood, but are primarily responsible to ensure that the neurons function in a strictly regulated homeostatic interstitium. Brain ... -
Association among sperm chromatin condensation, sperm DNA fragmentation and 8-OHdG in seminal plasma and semen parameters in infertile men with oligoasthenoteratozoospermia
(Wiley, 2021)The present study aimed to investigate the clinical role of standard sperm diagnosis parameters (sperm concentration, motility, morphology) as well as aniline blue staining of histones, 8-OHdG, TUNEL assay were performed ... -
The association between environmental exposures during childhood and the subsequent development of Crohn's Disease: A score analysis approach
(Public Library of Science, 2017)Background Environmental factors during childhood are thought to play a role in the aetiology of Crohn's Disease (CD). In South Africa, recently published work based on an investigation of 14 childhood environmental exposures ... -
The association between gender and tooth loss in a small rural population of South Africa
(Science Publishing Group, 2013)Periodontal disease, which attacks the gums and supporting structures of the tooth, is one of the major causes of tooth loss in adults. Few studies on general well-being have compared the differences in oral health between ... -
Association between promoter methylation of MLH1 and MSH2 and reactive oxygen species in oligozoospermic men—A pilot study
(Wiley, 2017)MLH1 and MSH2 are important genes for DNA mismatch repair and crossing over during meiosis and are implicated in male infertility. Therefore, the methylation patterns of the DNA mismatch repair genes MLH1 and MSH2 in ... -
Association of XRCC1 and ERCC2 promoters’ methylation with chromatin condensation and sperm DNA fragmentation in idiopathic oligoasthenoteratozoospermic men
(Blackwell Publishing Ltd, 2021)The aim of the study was to investigate whether the promoter methylation of XRCC1 and ERCC2 genes is associated with sperm DNA fragmentation and chromatin condensation in idiopathic oligoasthenoteratozoospermic men. This ... -
Autoimmune progesterone dermatitis: Case report with history of urticaria, petechiae and palpable pinpoint purpura triggered by medical abortion
(South African Medical Association, 2016)Autoimmune progesterone dermatitis (APD) is a rare autoimmune response to raised endogenous progesterone levels that occur during the luteal phase of the menstrual cycle. Cutaneous, mucosal lesions and other systemic ... -
Automation of human semen analysis using a novel artificial intelligence optical microscopic technology
(Wiley Online Library, 2019)Current semen analysis still commonly depends on a manual microscopy method in clinical laboratories worldwide. However, some of the major disadvantages of this technique are that it is labour‐intensive, subjective, ... -
Autosomal recessive congenital cataract in captive-bred vervet monkeys (Chlorocebus aethiops)
(Wiley, 2018)BACKGROUND: The aim of the study was to evaluate the genetic predisposition of congenital cataract in a colony of captive-bred vervet monkeys. METHODS: Four congenital cataract genes: glucosaminyl (N-acetyl) transferase ... -
B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients
(AOSIS, 2018)BACKGROUND: Altered immune mechanisms play a critical role in the pathogenesis of non- Hodgkin’s lymphoma (NHL). HIV-1 (HIV) infection is associated with a state of excessive T-cell activation, which can lead to increased ... -
Bacterial morphotype grading for periodontal disease assessment
(Nature Publishing Group, 2017)BACKGROUND: Listgarten and Hellden (1978) used darkfield microscopy of wet mounts to differentiate between healthy and periodontally diseased sites in the mouth by expressing the different bacterial morphotypes observed ... -
BANA-positive plaque samples are associated with oral hygiene practices and not CD4+ T cell counts in HIV-positive patients
(Hindawi Publishing Corporation, 2012)Background. The “red complex” microorganisms, namely, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia are considered as potential pathogens causing HIV-associated periodontal diseases. Moreover, ... -
The beneficial role of anchomanes difformis in stz-induced reproductive dysfunction in male wistar rats
(Dove Medical Press, 2020)Progression of diabetes mellitus has increasingly led to several diabetic complications. Diabetes is one of the major factors implicated in male reproductive system damage. Recent approaches such as the use of medicinal ... -
Bibliometrics: tracking research impact by selecting the appropriate metrics
(Medknow Publications, 2016)Traditionally, the success of a researcher is assessed by the number of publications he or she publishes in peer-reviewed, indexed, high impact journals. This essential yardstick, often referred to as the impact of a ... -
Biodegradable ceramics consisting of hydroxyapatite for orthopaedic implants
(MDPI, 2017)This study aims to analyze hydroxyapatite (HAP) coatings enriched with Mg and Ti prepared by a magnetron sputtering technique on Ti6Al4V substrate. For preparation of the coatings, three magnetron targets (HAP, MgO and ... -
Biosensors as early warning detection systems for waterborne cryptosporidium
(IWA Publishing, 2023)Waterborne disease is a global health threat contributing to a high burden of diarrhoeal disease, and growing evidence indicates a prospective increase in incidence coinciding with the profound effects of climate change. ... -
Biosynthesis of silver nanoparticles using Bersama engleriana fruits extracts and their potential inhibitory effect on resistant bacteria
(MDPI, 2022)The absence of novel, safe, and effective bactericide is an urgent concern worldwide and remains a challenge in scientific communities. The unique proprieties of silver nanoparticles (SNPs) synthesized from plant extracts ... -
Biosynthesis, Characterization, and Biological Activities of Procyanidin Capped Silver Nanoparticles
(Multidisciplinary Digital Publishing Institute, 2020-09-19)In this study, procyanidin dimers and Leucosidea sericea total extract (LSTE) were employed in the synthesis of silver nanoparticles (AgNPs) and characterized by ultraviolet-visible (UV-Visible) spectroscopy, high-resolution ...