Search
Now showing items 21-30 of 56
Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans
(Nature Publishing Group, 2017)
The Southern African Human Genome Programme is a national initiative that aspires to
unlock the unique genetic character of southern African populations for a better understanding
of human genetic diversity. In this pilot ...
A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer
(BioMed Central, 2018)
BACKGROUND: Gene expression can be employed for the discovery of prognostic gene or multigene signatures
cancer. In this study, we assessed the prognostic value of a 35-gene expression signature selected by pathway ...
Hackathons as a means of accelerating scientific discoveries and knowledge transfer
(Cold Spring Harbor Laboratory Press, 2018)
Scientific research plays a key role in the advancement of human knowledge and pursuit of solutions to important societal
challenges. Typically, research occurs within specific institutions where data are generated and ...
A meta-analysis of public microarray data identifies gene regulatory pathways deregulated in peripheral blood mononuclear cells from individuals with Systemic Lupus Erythematosus compared to those without
(BioMed Central, 2017)
BACKGROUND: Systemic Lupus Erythematosus (SLE) is a complex, multi-systemic, autoimmune disease for which the
underlying aetiological mechanisms are poorly understood. The genetic and molecular processes underlying ...
Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and available of integrase inhibitors in Cape Town, South Africa
(Nature Publishing Group, 2018)
HIV-Integrase (IN) has proven to be a viable target for highly specific HIV-1 therapy. We aimed to
characterize the HIV-1 IN gene in a South African context and identify resistance-associated mutations
(RAMs) against ...
Castleman’s disease in the HIV-endemic setting
(Dovepress, 2018)
Castleman’s disease (CD), first described by Benjamin Castleman in 1954, is a
giant or angiofollicular lymph node hyperplasia, described as a rare monotypic polyclonal B-cell
lymphoproliferative disorder with an incompletely ...
Effectiveness of sms technology on timely community health worker follow-up for childhood malnutrition: A retrospective cohort study in sub-Saharan Africa
(U.S. Agency for International Development, 2018)
The Millennium Villages Project facilitated technology-based health interventions in rural under-resourced areas of subSaharan Africa. Our study examined whether data entry using SMS compared with paper forms by community ...
Chromosomal-level assembly of the Asian seabass genome using long sequence reads and multi-layered scaffolding
(Public Library of Science, 2016)
We report here the ~670 Mb genome assembly of the Asian seabass (Lates calcarifer), a
tropical marine teleost. We used long-read sequencing augmented by transcriptomics, optical
and genetic mapping along with shared ...
Evidence of pervasive biologically functional secondary structures within the Genomes of Eukaryotic Single-Stranded DNA Viruses
(American Society for Microbiology, 2013)
Single-stranded DNA (ssDNA) viruses have genomes that are potentially capable of forming complex secondary structures
through Watson-Crick base pairing between their constituent nucleotides. A few of the structural elements ...
Evidence that dicot-infecting mastreviruses are particularly prone to inter-species recombination and have likely been circulating in Australia for longer than in Africa and the Middle East
(Elsevier, 2013)
Viruses of the genus Mastrevirus (family Geminiviridae) are transmitted by leafhoppers and infect either mono- or dicotyledonous plants. Here we have determined the full length sequences of 49 dicot-infecting mastrevirus ...