Browsing Medical Bioscience by Title
Now showing items 104-123 of 277
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Fiber type and metabolic characteristics of skeletal muscle in 16 breeds of domestic dogs
(Wiley, 2023)The domestic dog (Canis lupus familiaris) species comprises hundreds of breeds, each differing in physical characteristics, behavior, strength, and running capability. Very little is known about the skeletal muscle ... -
The flexible, extended coil of the pdz-binding motif of the three deadly human coronavirus e proteins plays a role in pathogenicity
(MDPI, 2022)The less virulent human (h) coronaviruses (CoVs) 229E, NL63, OC43, and HKU1 cause mild, self-limiting respiratory tract infections, while the more virulent SARS-CoV-1, MERS-CoV, and SARS-CoV-2 have caused severe outbreaks. ... -
Functional landscape of SARS-CoV-2 cellular restriction
(Cell Press, 2021)A deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus disease 2019 (COVID-19). To identify the molecular ... -
Further evidence for periodontal disease as a risk indicator for adverse pregnancy outcomes
(Elsevier, 2017)Although there is increasing evidence to suggest an association between periodontal disease and adverse pregnancy outcomes, the issue remains controversial. Study objective: This study tested the hypothesis that ... -
Genetic lesions within the 3a gene of SARS-CoV
(BioMed Central, 2005)A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical samples obtained from SARS-CoV ... -
The genetic organisation of a 2,966 basepair DNA fragment of a Single Capsid Nucleopolyhedrovirus isolated from Trichoplusia ni
(Springer Verlag, 2002)In order to investiagte the genomic organization of the Trichoplusia ni Single Capsid Nucleoplyhedrovirus (TnSNPV) , a 2,966 base pairs (bp) genomic fragment was sequenced. The fragment was found to contain five open reading ... -
A Global Survey of Reproductive Specialists to Determine the Clinical Utility of Oxidative Stress Testing and Antioxidant Use in Male Infertility
(The world journal of men's health, 2021)Globally, infertility impacts 15% of couples trying to conceive. The incidence of male infertility has been increasing over the past several decades, ranging from 20% to 70% worldwide [1,2]. The male partner is found to ... -
Green nanotechnology as an innovative drug delivery approach for typha capensis and naringenin—new class of phytochemical embedded biocompatible gold nanoparticles in prostate cancer therap
(Journal of Drug Delivery Science and Technology, 2022)Naringenin, a flavone with a growing body of evidence as an anti-cancer agent, is found in Typha capensis, an indigenous South African plant commonly used in traditional medicine. However, despite favourable in vitro ... -
Green tea (Camellia sinensis) aqueous extract improved human spermatozoa functions in vitro
(ResearchGate, 2022)Background: Idiopathic causes of infertility is associated with oxidative stress. Antioxidants are known to scavenge the excessive production of reactive oxygen species (ROS). Green tea (Camellia sinensis) contains polyphenols ... -
Green tea consumption increases sperm concentration and viability in male rats and is safe for reproductive, liver and kidney health
(Springer Nature, 2020)Green tea is a popularly consumed beverage worldwide and contains polyphenols, whose antioxidant activities could improve sperm parameters and fertility thereof. We investigated the effect of green tea on the male rat ... -
Group B streptococcus serotypes in pregnant women from the Western Cape region of South Africa
(Frontiers, 2018-12-04)Background: Maternal colonization of Group B streptococci (GBS) during pregnancy is an important risk factor for neonatal morbidity and mortality. The aim of this study was to determine the prevalence and serotype distribution ... -
High levels of oxidation–reduction potential in frozen-thawed human semen are significantly correlated with poor post-thaw sperm quality
(Wiley-Blackwell, 2020)This study examined the relationship between oxidation–reduction potential (ORP) in frozen-thawed semen and the post-thaw sperm parameters. Levels of ORP were measured in 25 samples from men presenting for routine infertility ... -
High-resolution insights into the in vitro developing blood-brain barrier: Novel morphological features of endothelial nanotube function
(Frontiers Media, 2021)High-resolution electron microscopy (HREM) imaging of the in vitro blood-brain barrier (BBB), is a promising modality for investigating the dynamic morphological interplay underpinning BBB development. The successful ... -
HIV/Candida co-infection in Sub-Saharan African women on ART
(Infectious Diseases Society of Southern Africa, the Sexually Transmitted Diseases Society of Southern and the Public Health Association of South Africa., 2013)INTRODUCTION: Sub-Saharan Africa has 23.5 million cases of HIV and is home to 92% of the world’s HIV-positive pregnant women of whom 24% die of pregnancy related complications. Oral candidiasis is a common condition in ... -
HPLC-MS identification and expression of Candida drug-resistance proteins from African HIV-infected patients
(AIMS Press, 2021-09-10)The objective of this study was to elucidate the proteomic mechanisms of drug resistance in HIV-infected African patients. Cell membrane fractions from forty oral Candida isolates isolated from African HIV-positive patients ... -
Human coronavirus NL63 open reading frame 3 encodes a virion-incorporated N-glycosylated membrane protein
(BioMed Central, 2010)Background: Human pathogenic coronavirus NL63 (hCoV-NL63) is a group 1 (alpha) coronavirus commonly associated with respiratory tract infections. In addition to known non-structural and structural proteins all coronaviruses ... -
Human coronavirus NL63: A clinically important virus?
(Future Science Group, 2011)Respiratory tract infection is a leading cause of morbidity and mortality worldwide, especially among young children. Human coronaviruses (HCoVs) have only recently been shown to cause both lower and upper respiratory tract ... -
Human coronavirus research: 20 years since the SARS-CoV outbreak
(Frontiers Media, 2022)This Editorial introduces 10 articles published in a Special Issue highlighting human coronavirus (hCoV) research on the twentieth anniversary of the outbreak of severe acute respiratory syndrome (SARS) in late 2002. ... -
Human coronaviruses: counteracting the damage by storm
(MDPI Viruses, 2021)Over the past 18 years, three highly pathogenic human (h) coronaviruses (CoVs) have caused severe outbreaks, the most recent causative agent, SARS-CoV-2, being the first to cause a pandemic. Although much progress has been ... -
Human sperm handling in intracytoplasmic sperm injection processes: In vitro studies on mouse oocyte activation, embryo development competence and sperm oxidation–reduction potential
(Wiley, 2018)Polyvinylpyrrolidone (PVP) and hyaluronic acid (HA) are routinely used in handling spermatozoa for intracytoplasmic sperm injection (ICSI). As there are still concerns about possible adverse effects on the embryo, this ...