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A retrospective descriptive investigation of adult patients receiving third-line antiretroviral therapy in the North West province, South Africa
(Makerere University, 2020)
Greater access and prolonged exposure to ART may inevitably lead to more treatment failure and increase the need for third-line ART (TLART) in a resource-limited setting. Objective: To describe characteristics and resistance ...
A pharmacist-led prospective antibiotic stewardship intervention improves compliance to community-acquired pneumonia guidelines in 39 public and private hospitals across South Africa
(Elsevier, 2020)
Introduction: Pharmacists in low-middle-income countries (LMIC) are few and lack antibiotic stewardship (AS) training. The ability was assessed of non-specialised pharmacists to implement stewardship interventions and ...
Exploring the utility of a spontaneous adverse drug reaction reporting system in identifying drug–drug interactions between antiretrovirals, antitubercular drugs, and cotrimoxazole: a case/non-case analysis
(Springer Nature, 2020)
Background: Drug–drug interactions (DDIs) cause significant morbidity and mortality, especially in patients with HIV with opportunistic infections such as tuberculosis. However, the literature on quantitative signal detection ...
Development of a method to determine the cost of breast cancer treatment with chemotherapy at Groote Schuur Hospital, Cape Town, South Africa
(SAMA, 2020)
There has been no comprehensive study determining the financial burden of breast cancer in the South African (SA) public sector. Objectives. To develop a method to determine the cost of breast cancer treatment with ...
Assessment of Vancomycin Pharmacokinetics and Dose Regimen Optimisation in Preterm Neonates
(Springer Nature, 2020)
The pharmacokinetics of vancomycin, a drug used for the treatment of methicillin-resistant Staphylococcus
aureus (MRSA), varies between paediatric and adult patients.
The objective of this study was to assess the ...
Antibacterial Activities of Selected Green Seaweeds from West African Coast
(EC Pharmacology and Toxicology ECronicon Open Access, 2020)
The continually increasing antibiotic resistance amongst microorganisms had steered up an increased intensity in the search
for new drugs. The marine environment had been reported to be a great source of novel compounds ...
4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as nmda receptor- And VGCC blockers with neuroprotective potential
(MPDI, 2020)
The impact of excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptor overactivation and voltage gated calcium channel (VGCC) depolarization is prominent among the postulated processes involved in the development ...
Synthesis of 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as lead scaffolds for neuroprotective agents
(Arkat USA, 2020)
Neurodegenerative disorders are characterised by progressive loss of neuronal functions. Of the proposed mechanisms, excitotoxicity, mediated by prolonged glutamate activation and calcium overload, is prominent. NGP1-01, ...
Mechanochemical synthesis and physicochemical characterization of isoniazid and pyrazinamide co-crystals with Glutaric acid
(Frontiers Media S.A., 2020)
The present work reports two novel pharmaceutical co-crystals; 2:1 isoniazid-glutaric acid (INHGA) and 2:1 pyrazinamide-glutaric acid (PGA). Isoniazid and pyrazinamide are key first-line drugs used for the treatment of ...
Encapsulation of variabilin in stearic acid solid lipid nanoparticles enhances its anticancer activity in vitro
(MDPI, 2020)
The use of natural products as chemotherapeutic agents is well established; however, many of these are associated with undesirable side effects, including high toxicity and instability. Furthermore, the development of drug ...