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Now showing items 11-20 of 23
Amitriptyline prescribing in public sector healthcare facilities in the Western Cape, South Africa
(Public Library of Science, 2020)
Inappropriate medication use is a major patient safety concern, especially for the elderly population. Amitriptyline is widely used in primary care in South Africa and a cross-sectional study found that amitriptyline was ...
Establishing a pharmacist–prescriber partnership in publicly funded primary healthcare clinics to optimisantibiotic prescribing in the Western Cape: An exploratory study
(Taylor & Francis, 2020)
Promoting evidence-based antibiotic prescribing through successful antimicrobial stewardship (AMS) programmes is critical to preserving the effectiveness of antibiotics for common infections in primary care. This requires ...
An analysis of the trends, characteristics, scope, and performance of the Zimbabwean pharmacovigilance reporting scheme
(Wiley-Blackwell, 2020)
We aimed to determine the reporting trends and characteristics of Individual Case
Safety Reports (ICSRs) from the Zimbabwean national pharmacovigilance system.
ICSRs submitted to VigiBaseTM, the World Health Organisation's ...
Synthesis, physicochemical characterization, toxicity and efficacy of a PEG conjugate and a hybrid PEG conjugate nanoparticle formulation of the antibiotic moxifloxacin
(Royal Society of Chemistry, 2020)
Antibiotic resistance is increasing at such an alarming rate that it is now one of the greatest global health challenges. Undesirable toxic side-effects of the drugs lead to high rates of non-completion of treatment regimens ...
Novel South African rare actinomycete kribbella speibonae Strain SK5: A prolific producer of hydroxamate siderophores including new dehydroxylated congeners
(MDPI, 2020)
In this paper, we report on the chemistry of the rare South African Actinomycete Kribbella speibonae strain SK5, a prolific producer of hydroxamate siderophores and their congeners. Two new analogues, dehydroxylated ...
4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potential
(MDPI, 2020)
The impact of excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptor
overactivation and voltage gated calcium channel (VGCC) depolarization is prominent among
the postulated processes involved in the development ...
Synthesis of 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as lead scaffolds for neuroprotective agents
(Arkivoc, 2020-09)
Neurodegenerative disorders are characterised by progressive loss of neuronal functions. Of the proposed mechanisms, excitotoxicity, mediated by prolonged glutamate activation and calcium overload, is prominent. NGP1-01, ...
Synthesis of 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as lead scaffolds for neuroprotective agents
(Arkivoc, 2020-09)
Neurodegenerative disorders are characterised by progressive loss of neuronal functions. Of the proposed mechanisms, excitotoxicity, mediated by prolonged glutamate activation and calcium overload, is prominent. NGP1-01, ...
Pharmaceutical co-crystal: An alternative strategy for enhanced physicochemical properties and drug synergy
(Wiley Open Access, 2020)
A growing number of co-crystals in the literature are proof of how significant
the co-crystallization concept has become. Co-crystallization enhances
physicochemical properties through the formation of intermolecular ...
Synthesis of 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as lead scaffolds for neuroprotective agents
(ARKAT USA, 2020)
Neurodegenerative disorders are characterised by progressive loss of neuronal functions. Of the proposed mechanisms, excitotoxicity, mediated by prolonged glutamate activation and calcium overload, is prominent. NGP1-01, ...